Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00647179

Enrollment

Registered

2008-03-31

Start date

2008-02-29

Completion date

2016-12-07

Last updated

2017-12-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acromegaly, Excessive Growth Hormone Secretion, Insulin Resistance

Keywords

Acromegaly, Growth Hormone, Insulin resistance, Glucose tolerance, Body Composition, Substrate metabolism

Brief summary

The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.

Interventions

PROCEDURETranssphenoidal adenomectomy

Surgery

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Written consent * Age between 18 and 70 * Recently diagnosed with acromegaly

Exclusion criteria

* NYHA 3 * Uncontrolled hypertension * Known cerebrovascular disease * Proliferative retinopatia

Design outcomes

Primary

Measure	Time frame
Insulin sensitivity	Before and after treatment

Secondary

Measure	Time frame
QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism, Glucose tolerance	Before and after treatment

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 20, 2026