Growth Hormone Deficiency
Conditions
Keywords
insulin sensitivity, substrate metabolism, fatty liver, intramyocellular lipids, growth hormone deficiency, Growth hormone deficiency (Adult)
Brief summary
The purpose of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic-intramyocellular lipids in patients with growth hormone deficiency (GHD).
Interventions
Dosage regulation will follow the local recommendations of GHD treatment
Sponsors
Aarhus University Hospital
University of Aarhus
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Written informed consent * Must be of legal age and competent * Age: \>18 and \<60 years old * Presently diagnosed with growth hormone deficiency; if panhypopituitary, the patient must be sufficiently substituted in the other axis´s, for at least 3 months before inclusion in the study
Exclusion criteria
* Alcohol consumption \>21 units per week * Malignant disease * Pregnancy * Magnetic implants or material in the body * Claustrophobia * BMI \>30 * Heart disease (NYHA \>2) * Uncontrolled hypertension * Manifest diabetes mellitus * Change in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial. Controls are matched on age, gender and BMI Inclusion Criteria: * Written informed consent * Must be of legal age and competent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| insulin sensitivity | before and after 3 months treatment with growth hormone |
Secondary
| Measure | Time frame |
|---|---|
| substrate metabolism | before and after 3 months of growth hormone treatment |
| intrahepatic lipid content | before and after 3 months of growth hormone treatment |
| intramyocellular lipid content | before and after 3 months of growth hormone treatment |
Countries
Denmark
Outcome results
None listed