Asthma
Conditions
Keywords
asthma, bronchodilatation, Symbicort, budesonide/formoterol, Advair Diskus, Ventolin
Brief summary
The purpose of this study is to compare the early onset of effect of Symbicort compared to Advair Diskus and Ventolin in adults with asthma
Interventions
DRUGfluticasone/salmeterol (Advair Diskus)
DRUGalbuterol (Ventolin)
Sponsors
AstraZeneca
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of asthma and baseline lung function test results as determined by protocol * Required and received asthma maintenance therapy within previous 4 weeks at doses determined by protocol
Exclusion criteria
* Severe asthma or asthma markedly affected by seasonal factors * Has required treatment with any non-inhaled corticosteroids within previous 4 weeks, has sensitivity to drugs specified in the protocol or requires treatment with beta-blockers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FEV1 3 minutes post dose | 4 assessments across 4 visits whilst on treatment (visits may be between 3 and 14 days apart) |
Secondary
| Measure | Time frame |
|---|---|
| 12 hour serial FEV1 | 4 assessments across 4 visits whilst on treatment (visits may be between 3 and 14 days apart) |
| Patients perception of effect | 4 assessments across 4 visits whilst on treatment (visits may be between 3 and 14 days apart) |
Outcome results
None listed