Asymptomatic Parataemia, Plasmodium Falciparum, Sub Patent Parasitaemia
Conditions
Brief summary
The malaria parasite Plasmodium falciparum remains at sub-patent level throughout the dry season in areas of seasonal malaria transmission. Targeting this parasite reservoir before the transmission season could be a good strategy for malaria control. We are conducting a randomized double blind placebo controlled mass drug administration trial in eight village to clear the dry season low level parasitaemia with an ultimate aim of controlling malaria in eastern Sudan.
Interventions
DRUGSulfadoxine / Pyrimethamine (SP) plus artesunate (AS)
Standard three day regimen
DRUGplacebo tablet similar to active drug in shape and size
Dosage similar to active drug(standard three days regimen)
Sponsors
London School of Hygiene and Tropical Medicine
International Atomic Energy Agency
Tropical Medicine Research Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* All residents of the 8 villages
Exclusion criteria
* Pregnancy * History of allergy to sulfa drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parsitaemia detected during the transmission season among dry season PCR negative persons in the intervention and control villages | October to December 2006 |
Secondary
| Measure | Time frame |
|---|---|
| 1. Malaria prevalence during the transmission season 2. Frequency of mutation in drug resistance genes | — |
Countries
Sudan
Outcome results
None listed