T-Wave Alternans (TWA) Reproducibility in CAD Patients

Reproducibility of T Wave Alternans Testing in Patients With Ischemic Heart Disease.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00644345

Enrollment

100

Registered

2008-03-26

Start date

2008-05-31

Completion date

2009-05-31

Last updated

2008-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

Microvolt T wave alternans, reproducibility

Brief summary

Microvolt T-Wave Alternans (MTWA) is a relatively new non-invasive method for identifying patients at increased risk of sudden death from ventricular arrhythmias. MTWA can be measured during a routine exercise test, during pharmacologic stress or during cardiac pacing. Its clinical performance compares favorably with that of other non-invasive risk stratifiers and invasive electophysiologic studies. The purpose of the present study is to define the reproducibility of MTWA testing.

Detailed description

The study will be performed in the Cardiac Rehabilitation Center at Assaf Harofeh Medical Center. Patients with coronary artery disease will be eligible to enroll. Patient will undergo an exercise test on a stationary bicycle. TWA will be measured at heart rate of 105 and 115 BPM. The test will be repeated one week later in the same fashion. The patient will continue follow-up in the rehabilitation center as dictated by the rehabilitation program. Patients will be kept on their regular medications and there will be no change of the medications from the first TWA measurement to the second.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. Patients enrolled in the cardiac rehabilitation center program 2. Patients with CAD 3. Age \>18 and \< 80 YO 4. Patients with a pacemaker or defibrillator with normal AV conduction

Exclusion criteria

1. Patients with chronic AF 2. Patients with multiple APB's or PVC's 3. Patients who are unable to increase their heart rate to 115 BPM and don't have a pacemaker. 4. Patients who are unable to exercise on a bicycle.

Design outcomes

Primary

Measure	Time frame
Reproducibility of TWA test results	1 week

Secondary

Measure	Time frame
Ventricular arrhythmias during exercise	1 week

Countries

Israel

Contacts

Primary ContactTherese Fuchs, MD

fuchst@asaf.health.gov.il972-8-977-9735

Backup ContactIsaac Zysman, MD

zysmanI@asaf.health.gov.il972-8-977-9735

Outcome results