Bleb
Conditions
Keywords
injected bleb, mitomycin drop, 5-Fu injection, early bleb failure
Brief summary
purpose : to evaluate and compare the effectiveness and complication of 5-FU injections and MMC drop in management of early bleb failure . Design:Randomized clinical trial Methods:Patients with low injected bleb in first month after filtering or combined surgery with MMC which don't respond to high frequent topical steroids and removal of releasable sutures will be randomize to either 5-FU injection or Mitomycin drop 0.02%.For each patient slit photograph in first day of recruiting,first two weeks and first and third month will be obtained.Patients will follow for at least 3 months and IOP ,bleb configuration will check as primary outcome measures.Preoperative and postoperative data,complications,and the need for further surgical procedures will be evaluated.
Interventions
DRUG5-FU and Mitomycin
* 5-FU injection 5mg * Mitomycin drop 0.02%
Sponsors
Shahid Beheshti University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
8 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with low,injected bleb in first month after trabeculectomy or combined trabeculectomy&phaco which not respond to high frequent topical steroids or removal of releasable sutures
Exclusion criteria
* Injected bleb due to complications of surgery such as button hole formation * Injected bleb due to blebitis * Bleb leakage * Flat AC * Pregnant or nursing mothers * Injected bleb after bleb reconstruction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Iop and Bleb height,extent and vascularity | At least in 3 months of follow up |
Secondary
| Measure | Time frame |
|---|---|
| complication of 5-FU injection or Mitomycin drop in treatment of early bleb failure | — |
Countries
Iran
Contacts
Primary ContactMohammad pakravan, associated professor
Outcome results
None listed