Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

Helium:Oxygen Versus Air:Oxygen Nonivasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00642447

Enrollment

Registered

2008-03-25

Start date

2007-04-30

Completion date

Unknown

Last updated

2008-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchiolitis, Chronic Bronchitis

Keywords

noninvasive ventilation, helium, oxygen, sulfur mustard, chronic bronchitis, bronchiolitis

Brief summary

to assess the effect of Heliox with Noninvasive positive pressure ventilation to decrease dyspnea and improve physiologic and respiratory measures in patients with a previous exposure to Sulfur Mustard gas.

Interventions

DRUGhelium:oxygen mixture

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

38 Years to 59 Years

Healthy volunteers

Inclusion criteria

* exposure to sulfur mustard * worsening dyspnea during the last 10 days * respiratory rate of \>25/min * arterial pH\<7.35 * PaCO2 of \>50 mmHg * PaO2 of \<50 mmHg

Exclusion criteria

* recent pneumothorax (\<1 month) * severe respiratory failure or hemodynamic instability with forthcoming intubation * FIO2 of \<0.4 * impaired consciousness or absence of patient cooperation * facial lesions precluding NIPPV

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026