Keratoconus
Conditions
Keywords
Keratoconus
Brief summary
Cross-linking of the cornea increases the mechanical and biochemical stability of the stromal tissue. The purpose of this study is to assess the effectiveness of riboflavin-ultraviolet light induced cross-linking of corneal collagen in improving visual acuity and reducing progression of keratoconus in the Brazilian population.
Interventions
PROCEDURECorneal Collagen Crosslinking
UV light and Riboflavin eyedrops every 5 minutes for 30 minutes.
Sponsors
Universidade Federal do Rio de Janeiro
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Age from 18 to 35 years. * Diagnosis of Keratoconus. * Progression of Ametropia. * Written informed consent.
Exclusion criteria
* Corneal Thickness \< 395 micra at thinnest point. * Other active ocular disease than keratectasia. * Cornea Guttata. * Previous ocular surgery. * Pregnancy. * Known sensitivity to riboflavin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Keratometry | 3 months |
| BSCVA (Best spectacle corrected visual acuity) | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Endothelial cell count | 3 months |
Countries
Brazil
Contacts
Primary ContactRicardo Lamy, MD
Outcome results
None listed