Arterial Stiffness, End Stage Renal Disease
Conditions
Keywords
arterial stiffness, artery, aortic pulse wave velocity, pulse wave analysis, augmentation index, end stage renal disease, nocturnal hemodialysis, extended hours of hemodialysis, cardiovascular, hemodialysis
Brief summary
Arterial stiffness refers to the accumulation of extracellular deposits of matrix and calcium which reduce blood vessel compliance. Although there is growing evidence that increased arterial stiffness is associated with chronic kidney disease (CKD), its pathogenesis is unclear. Pulse wave velocity (PWV) and augmentation index (AIx) provide tools for estimating arterial stiffness, and therefore predicting cardiovascular morbidity and mortality. The aims of the study are: (1) compare the effects of nocturnal and conventional haemodialysis on arterial stiffness, and (2) examine the relationship between arterial stiffness and clinical and biochemical parameters.
Interventions
PROCEDURENocturnal Hemodialysis
Sponsors
Melbourne Health
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* adult dialysis patients * able to perform home nocturnal haemodialysis
Exclusion criteria
* age \< 18 and \> 80 years * any patient who is anticipating a live renal transplantation in forthcoming 12 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To purpose of this study is to evaluate the arterial stiffness in subjects who have undergone 12 months nocturnal haemodialysis. | 12 months |
Secondary
| Measure | Time frame |
|---|---|
| To examine the relationship between arterial stiffness and clinical and biochemical parameters | 12 months |
Outcome results
None listed