Parkinson's Disease
Conditions
Keywords
Parkinson's disease, impulse control behaviors, dopa-dysregulation
Brief summary
The purpose of this study is to determine how many patients with Parkinson's disease have compulsive behaviors, and what types of behaviors they have. This study will also determine if acamprosate can be used to treat compulsive behaviors in Parkinson's disease patients.
Interventions
DRUGacamprosate
333 mg 2 tabs tid
Sponsors
National Parkinson Foundation
Baylor College of Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Idiopathic Parkinson's disease 2. Active dopaminergic therapy at stable dose for one month (levodopa or dopamine agonist) 3. Able and willing to complete Rating Scales 4. Presence of one or more compulsive behavior based on responses to Rating Scales (defined as \>5 on the SOGS; \>17 on the YBOCS-SV and YBOCS-CUV; \>1.7 on the SCS for women and \>2.1 on the SCS for men; \>15 on the YBOCS-BE, \>5.5 on the CQ). 5. Written informed consent Inclusion criteria (controls): 1. No significant psychiatric disease 2. Able and willing to complete Rating Scales 3. Written informed consent
Exclusion criteria
1. No anticipated need for adjustment of medications for Parkinson's disease 2. Current participation in another clinical study 3. History of unstable psychiatric disease (as determined by the Principal Investigator) 4. Women of childbearing age not using appropriate contraceptive methods (oral contraceptives, condoms, surgery)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| safety and efficacy compared to baseline scores | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| change from baseline assessment tools used in the study | 6 months |
Countries
United States
Outcome results
None listed