Acute Lung Injury, Brain Injury
Conditions
Keywords
Intraabdominal pressure
Brief summary
The hypothesis is that brain injury patients have alterations of the respiratory system related to intraabdominal pressure. Furthermore application of moderate levels of PEEP may improve respiratory function in these patients.
Detailed description
We investigate the mechanical properties of the respiratory system, partitioned into its lung and chest wall components, the functional residual capacity, the gas-exchange and alveolar recruitment in brain injured patients. The measurements will be performed under sedation at different levels of PEEP. The following groups will be included: a) control patients withot lung injury and brain injury; b) brain injured patients without lung injury within the first 72 hours; c) brain injured patients without lung injury after 72 hours; d) brain injured patients with lung injury. Brain injury was defined as primary or secondary. Respiratory functional data will be related to intra-abdominal pressure.
Interventions
OTHERPEEP
Application of positive end expiratory pressure
Sponsors
Università degli Studi dell'Insubria
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male and Female * Age \> 18 yrs * Mechanical ventilation * No smoker * No lung injury at entry * Brain injury (traumatic or postoperative or spontaneous bleeding) in brain injury group
Exclusion criteria
* Pregnancy * Hemodynamic instability * Immunodepression
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of respiratory function with PEEP | 30 min |
Secondary
| Measure | Time frame |
|---|---|
| Relations of respiratory mechanics (lung and chest wall) with intraabdominal pressure | 30 min |
Countries
Italy
Contacts
Primary ContactPaolo Pelosi, MD
Outcome results
None listed