Metabolic Syndrome
Conditions
Keywords
Uric acid, Fructose, Hypertension, Insulin, Glucose, HOMA
Brief summary
Studies in animals have found that allopurinol can markedly improve fructose induced metabolic syndrome. In this study we test the hypothesis that allopurinol may lower BP, reduce triglycerides, and improve metabolic parameters in subjects placed on a high fructose diet.
Detailed description
60 male subjects, age 40 to 65 years of age, will be placed on a 3500kcal (55% carbohydrates containing 200 g fructose) for 2 weeks. Half will receive allopurinol mg/day (randomized). At the end of 2 weeks we measure a variety of parameters including fasting glucose and insulin levels (with calculation of HOMA index), serum lipids (including triglycerides and LDL/HDL cholesterol), sitting blood pressure, serum uric acid, weight, and various other measurements (C reactive protein, adiponectin and leptin levels, and urate redox products). Primary endpoint is insulin resistance. Secondary endpoints are blood pressure, lipids, uric acid, weight.
Interventions
DRUGAllopurinol
Allopurinol 300 mg
DRUGPlacebo
Placebo given for 2 weeks
Sponsors
Hospital Mateo Orfila
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
40 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Males, age 40 -65 yrs
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin resistance (HOMA index) | 2 weeks |
| Blood pressure | 2 weeks |
| Triglycerides, HDL cholesterol | 2 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Adiponectin | 2 weeks |
| Weight gain | 2 weeks |
| Leptin | 2 weeks |
| CRP level | 2 weeks |
Countries
Spain
Outcome results
None listed