Diabetes
Conditions
Keywords
Cocoa, diabetes, polyphenols
Brief summary
Observing how cocoa effects the cardiovascular and renal system.
Detailed description
Study designed to assess the vascular benefits of drinking Cocoa that is rich in polyphenols. Vascular beds studied will include kidney, brain, eye, and periphery (finger). Time course of the effects will be studied in healthy normal (including elderly), and also in subjects with Type I and Type II diabetes. Renal blood flow will be determined by PAH/In u test clearance. Cranial ultrasound will be used to measure brain blood flow. Retinal blood flow will be assessed by specialized ultrasound/doppler device. Peripheral blood flow is measured by plethysmography. Urine and blood samples will be assayed for routine physiologic parameters, including hormone assessment, and also for the presence of cocoa metabolites.
Interventions
OTHERCocoa
Polyphenol rich or poor cocoa was administered to study subjects to measure hemodynamic responses and the role of nitric oxide in the renal vasodilator response.
Sponsors
MasterFoods
Brigham and Women's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
Diabetes (Type I and II), with or without Hypertension, blood pressure \<165/105
Exclusion criteria
Under 18 or over 85 years old, women who are pregnant or able to become pregnant, history of heart attack, stroke or chest pain within the past 6 months, kidney disease, heart disease, severe high blood pressure not controlled by medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic Measurements | Hourly measurements (5-6 hours total) |
Secondary
| Measure | Time frame |
|---|---|
| Blood Pressure | Hourly (5-6 hours) |
Countries
United States
Outcome results
None listed