Urinary Tract Infections
Conditions
Keywords
Urinary Tract Infections, Cranberry, Prevention
Brief summary
The objective of the study is to determine whether recurrences of urinary tract infection in children can be prevented with cranberry juice.
Detailed description
Five percent of children have at least one UTI episode and 30% of these episodes recur. Recurrences and the risk of renal damage are indications for long term antimicrobial prophylaxis, but emerging antimicrobial resistance underlines the need for alternatives. The bacteria causing urinary tract infection arise from the stools. Dietary changes can alter the balance of faecal bacteria. Vaccinium berries and products containing lactobacilli have been shown to act against the coliform bacteria that cause most urinary tract infections. In our previous study cranberry juice was effective in preventing symptomatic recurrences of urinary tract infections in women. The objective of our study is to determine whether recurrences of urinary tract infection in children can be prevented with cranberry juice.
Interventions
BIOLOGICALCranberry juice
5 ml/kg up to 300 ml, 1-2 doses daily for six months
BIOLOGICALPlacebo juice
5 ml/kg up to 300 ml, 1-2 doses daily for six months
Sponsors
Ocean Spray, Inc.
University of Oulu
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
* Urinary Tract Infection 0-2 months priorly
Exclusion criteria
* Antibiotic Prophylaxis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of the first recurrence | 12 months |
Secondary
| Measure | Time frame |
|---|---|
| Total number of UTI episodes and use of antimicrobials | 12 months |
Countries
Finland
Outcome results
None listed