Prostate Cancer
Conditions
Keywords
prostate cancer, venography, male patients, Localized microscopic prostate cancer up to Gleason 6 (3+3), PSA level <14, presence of varicocele
Brief summary
Patients with varicocele in whon early prostate cancer will be found will undergo venographic embolization of both spermatic veins. The study hypothesis is that this procedure will induce a gradual regression of the prostate volume that may decrease prostate cancer cells. Close follow-up will ensure that necessary therapy will be provided if needed according to clinical criteria. Results in terms of prostate size PSA level and tumor size will be recorded.
Interventions
PROCEDUREvenographic occlusion of spermatic veins
Through the femoral vein a catheter is inserted into the spermatic veins in succession and the veins are occluded.
Sponsors
Maaynei Hayesha Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Males age 45-75 * Prostate cancer * Presence of varicocele * No contraindication for venography
Exclusion criteria
* Diseases or medications which prevent interventional vascular procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety performance of the procedure. The change in tumor size and prostate cancer cells as evaluated by trans-rectal ultrasound and prostate biopsy | one year |
Secondary
| Measure | Time frame |
|---|---|
| The change in size of the prostate as evaluated by ultrasound Change in PSA value. Reduction of above 20% in nocturia | one year |
Countries
Israel
Outcome results
None listed