A Randomised Comparison on the Dose Requirement Between, Levobupivacaine, Ropivacaine and Bupivacaine in Intrathecal Anaesthesia

Minimum Local Anaesthetic Dose for Intrathecal Anaesthesia: a Randomised Comparison Between Levobupivacaine, Ropivacaine and Bupivacaine

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00636974

Enrollment

Registered

2008-03-17

Start date

2006-01-31

Completion date

2008-07-31

Last updated

2013-10-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Conduction, Surgery

Keywords

Patients who are going to have regional anaesthesia for lower limbs surgery., Leg Surgery.

Brief summary

To determine and compare the effective intrathecal dose of levobupivacaine, ropivacaine and bupivacaine for 50% of patients in lower limb surgery

Interventions

PROCEDURECombined spinal epidural anaesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* body weight=40-90kg, * height higher than 145cm

Exclusion criteria

* Known hypersensitivity to amide local anaesthetics, * patients who do not understand English and Chinese, * Body mass index higher than 35 kg per sq metre

Design outcomes

Primary

Measure	Time frame
Sensory block at 12th thoracic dermatome or above and successful conduct of the lower limb surgery up to 50 minutes after the intrathecal injection of the study drug	50 minutes after the intrathecal injection of the study drug

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026