Erectile Dysfunction
Conditions
Keywords
Obesity, Lifestyle changes
Brief summary
Healthy lifestyle factors are associated with maintenance of erectile function in men. To determine the effect of weight loss and increased physical activity on erectile and endothelial functions in obese men. Randomized, single-blind trial of 110 obese men without diabetes, hypertension, or hyperlipidemia, who had erectile dysfunction that was determined by having a score of 21 or less on the International Index of Erectile Function (IIEF). The 55 men randomly assigned to the intervention group received detailed advice about how to achieve a loss of 10% or more in their total body weight by reducing caloric intake and increasing their level of physical activity. Men in the control group (n = 55) were given general information about healthy food choices and exercise.
Interventions
BEHAVIORALLifestyle - detailed advice
Detailed advice about how to achieve a loss of 10% or more in their total body weight by reducing caloric intake and increasing their level of physical activity
BEHAVIORALControl - general information
General information about healthy food choices and exercise
Sponsors
University of Campania Luigi Vanvitelli
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
35 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Obese, sedentary (\<1 hour per week of physical activity) men with erectile dysfunction (a IIEF score lower than 22)and no evidence of participation in diet reduction programs within the last 6 months
Exclusion criteria
* Diabetes mellitus or impaired glucose tolerance (plasma glucose levels of 140-200 mg/dL \[7.8-11.1 mmol/L\] 2 hours after a 75-g oral glucose load) * Impaired renal function, including macroalbuminuria, pelvic trauma, prostatic disease, peripheral or autonomic neuropathy * Hypertension (blood pressure \>140/90 mm Hg) * Cardiovascular disease * Psychiatric problems * Use of drugs or alcohol abuse (500 g of alcohol per week in the last year).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IIEF (International Index Erectile Function) | two years |
Secondary
| Measure | Time frame |
|---|---|
| Endothelial function, Circulating inflammatory markers | two years |
Outcome results
None listed