Pregnancy
Conditions
Keywords
Amniotic fluid index, maternal hydration, isotonic solution, Amniotic Fluid
Brief summary
The purpose of this study is to determine the effect of maternal hydration with oral isotonic solution and water on amniotic fluid (AF) index in women with normohydramnios.
Detailed description
Objective: To determine the effect of maternal hydration with oral isotonic solution and water on amniotic fluid (AF) index in women with normohydramnios. Subjects and Methods: Women with normal AF index and gestational age between the 33 and 36 weeks without maternal complications were randomized into three groups (isotonic solution, water, control). The isotonic solution and water groups were instructed to drink 1.5L of respective solution; the control group was instructed to drink 200mL of water. AF index was measured before and after hydration. The investigator performing the AF index was blinded to the subject's group. Results: Ninety-nine women completed the study without any maternal adverse effects. The mean increase in amniotic fluid index after hydration was significantly greater in the isotonic solution and water groups (12.1mm, p=0.02; 13.1mm, p=0.05; respectively) than the control group (1.4mm, p=0.74). There was no significant difference between the isotonic solution and water groups. Hydration with isotonic solution and water improved the chance of 20% of increase of amniotic fluid index in 10.2 (95% CI 1.9-98.9) and 6.0 (95% CI 1.0-45.5) times respectively. Conclusion: Maternal hydration with isotonic solution or water increased AF index in women with normohydramnios.
Interventions
OTHERisotonic solution
1.5 L- during 2-4hours
OTHERwater
1.5 L- during 2-4hours
Sponsors
UPECLIN HC FM Botucatu Unesp
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* gestational age between 33 and 36 weeks * singleton pregnancy * intact membranes * initial AF index between 5 and 95 per cent
Exclusion criteria
* no maternal complications * no fetal structural malformation * no evidence of fetal distress on nonstress test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the effects of maternal oral hydration with isotonic fluid and water on amniotic fluid index in women with normohydramnios | 4horas |
Secondary
| Measure | Time frame |
|---|---|
| compare the effects of maternal oral hydration with isotonic fluid and water on amniotic fluid index in women with normohydramnios | 4horas |
Countries
Brazil
Outcome results
None listed