Alcohol Dependence
Conditions
Keywords
Alcohol Dependence, Alcoholism, Glycine, D-Cycloserine
Brief summary
Question #1: Will glycine ameliorate cognitive deficits? Hypothesis #1: Based on positive findings conducted with glycine and milacemide, a glycine prodrug, in schizophrenia and dementia, we expect that glycine will ameliorate cognitive deficits. Question #2: Will alcoholic patients show enhanced endocrinal effects to glycine? Hypothesis #2: Based on the dose-related effects of glycine in healthy subjects, we expect that glycine will increase the endocrinal response to glycine in alcoholic patients with, supposedly, dysregulated NMDA receptor function. Question #3: Will D-cycloserine have ethanol-like effects? Hypothesis #3: If inhibition of NMDA receptor function is fundamental to the subjective effects of ethanol, then the NMDA antagonist properties of D-cycloserine should be recognized as ethanol-like (relative to placebo) in recently detoxified alcoholics and healthy subjects. Question #4: Will D-cycloserine reverse cognitive benefits of glycine? Hypothesis 4: Based on the dose related NMDA antagonist activity of D-cycloserine, we expect that D-cycloserine will compete with the agonist activity of glycine and therefore it will reverse the cognitive benefits of glycine. Question #5: Will D-cycloserine inhibit endocrinal effects of glycine? Hypothesis #5: If the agonist activity of glycine is necessary to determine endocrine response, then the dose-related NMDA antagonist properties of D-cycloserine should block these effects.
Detailed description
The purpose of this study is to investigate the interaction between glycine and D-cycloserine in alcoholic patients and healthy subjects. Preclinical studies have shown that compounds acting at the glycine site of the N-methyl-D-aspartate (NMDA) receptor complex, such as glycine, may reverse the effects of ethanol on the NMDA receptor function (Rabe et al., 1990). The amino acid glycine is a co-agonist of the NMDA receptor complex (Kemp et al., 1993). It binds to the strychnine-insensitive site and positively modulates the NMDA receptor (Mc Donald et al., 1990). Physiologically, the glycine site is not saturated, and administration of glycine can potentiate NMDA receptor mediated responses. In contrast, D-cycloserine (Hood et al., 1989) is a partial-agonist at the glycine site of the NMDA receptor, with dose-dependent NMDA antagonist properties. The NMDA antagonist activity of D-cycloserine should produce ethanol like-effects that can be reversed by the agonist glycine. This study is intended to evaluate possible contributions of the glycine site to the reduction of cognitive deficits of alcoholism and complements the current work at VA Connecticut Healthcare System on the NMDA antagonists in alcoholic and healthy subjects.
Interventions
DRUGD-Cycloserine PO and Glycine IV
Test days will involve administration of D-Cycloserine in the morning in pill form then 4 hours later a 30 minute infusion of Glycine.
DRUGPlacebo D-Cycloserine PO and placebo Glycine IV
Placebo
DRUGPlacebo D-Cycloserine PO and Glycine IV
DRUGD-Cycloserine PO and placebo Glycine IV
Sponsors
Yale University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion /
Exclusion criteria
Alcoholic subjects: * Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 70 yrs. * Meet Diagnostic and Statistical Manual (DSM) IV criteria for alcohol dependence by structured clinical interview * Meet von Knorring criteria for early onset (type II) alcoholism * Without other DSM IV Axis I diagnoses by Structured Clinical Interview (SCID). * Without lifetime history of other substance abuse diagnosis by SCID (excluding tobacco) and urine toxicology screen negative for drug of abuse. * Medically and neurologically healthy on the basis of history, physical examination, sequential multiple analysis-computer (SMAC-20), complete blood count (CBC) w/diff. and EKG. In light of the proximity to alcohol dependence, liver function test (LFT) elevations of twice normal will be accepted into the study. * Patients with stable medical problems may be included in the study if their medications have not been adjusted in the month prior to participation and if these medications lack prominent central nervous system (CNS) effects. * Absence of alcohol within the past 15 days. * Patients must be free of medications utilized to facilitate detoxification (lorazepam, oxazepam) for at least 3 days prior to initiating testing. * Patients must have no history of alcoholic hallucinosis. * Patients must not be in acute alcohol withdrawal as evidence by a score no more than 2 for each item of the Clinical Institute Withdrawal Assessment Scale * Patients taking ethionamide or isoniazid will be not be allowed to participate in the study. Inclusion /
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual Analog Scales of Similarity to Alcohol - Baseline | Baseline | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | 60 minutes prior to Glycine infusion | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Visual Analog Scales of Similarity to Alcohol 30 Minutes | 30 minutes | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Visual Analog Scales of Similarity to Alcohol 60 Minutes | 60 minutes | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Visual Analog Scales of Similarity to Alcohol 120 Minutes | 120 minutes | Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation 60 Minutes Prior to Glycine Infusion | 60 minutes prior to Glycine infusion | Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol |
| Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 30 Minutes | 30 minutes | Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol |
| Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 60 Minutes | 60 minutes | Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol |
| Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 120 Minutes | 120 minutes | Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol |
| Visual Analog Scales (VAS) - Baseline | Baseline | Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) |
| Visual Analog Scales (VAS) - 60 Minutes Prior to Glycine Infusion | 60 minutes prior to Glycine infusion | Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) |
| Visual Analog Scales (VAS) - 30 Minutes | 30 minutes | Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) |
| Visual Analog Scales (VAS) - 60 Minutes | 60 minutes | Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) |
| Visual Analog Scales (VAS) - 120 Minutes | 120 minutes | Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely) |
| Alcohol Craving Scale (ACS) Subscale: Desire to Drink- Baseline | Baseline | Alcohol Craving Scale (ACS) Subscale: Desire to drink: Self-report rating scale used to measure desire to drink alcohol (0 No desire to drink alcohol - 100 Definitely desire to drink alcohol) |
| Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes Prior to Glycine Infusion | 60 minutes prior to Glycine infusion | Alcohol Craving Scale (ACS) Subscale: Desire to drink: Self-report rating scale used to measure desire to drink alcohol (0 No desire to drink alcohol - 100 Definitely desire to drink alcohol) |
| Alcohol Craving Scale (ACS) Subscale: Desire to Drink: - 30 Minutes | 30 minutes | Alcohol Craving Scale (ACS) Subscale: Desire to drink: Self-report rating scale used to measure desire to drink alcohol (0 No desire to drink alcohol - 100 Definitely desire to drink alcohol) |
| Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes | 60 minutes | Alcohol Craving Scale (ACS) Subscale: Desire to drink: Self-report rating scale used to measure desire to drink alcohol (0 No desire to drink alcohol - 100 Definitely desire to drink alcohol) |
| Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 120 Minutes | 120 minutes | Alcohol Craving Scale (ACS) Subscale: Desire to drink: Self-report rating scale used to measure desire to drink alcohol (0 No desire to drink alcohol - 100 Definitely desire to drink alcohol) |
| Alcohol Craving Scale (ACS) Subscale: Mood Improvement - Baseline | Baseline | Alcohol Craving Scale (ACS) Subscale: Mood improvement : Self-report rating scale used to measure expected alcohol-related mood improvement (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes Prior to Glycine Infusion | 60 minutes prior to Glycine infusion | Alcohol Craving Scale (ACS) Subscale: Mood improvement : Self-report rating scale used to measure expected alcohol-related mood improvement (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 30 Minutes | 30 minutes | Alcohol Craving Scale (ACS) Subscale: Mood improvement : Self-report rating scale used to measure expected alcohol-related mood improvement (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes | 60 minutes | Alcohol Craving Scale (ACS) Subscale: Mood improvement : Self-report rating scale used to measure expected alcohol-related mood improvement (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 120 Minutes | 120 minutes | Alcohol Craving Scale (ACS) Subscale: Mood improvement : Self-report rating scale used to measure expected alcohol-related mood improvement (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Discomfort - Baseline | Baseline | Alcohol Craving Scale (ACS) Subscale: Discomfort: Self-report rating scale - subscale reflecting expected alcohol-related relief from discomfort (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes Prior to Glycine Infusion | 60 minutes prior to Glycine infusion | Alcohol Craving Scale (ACS) Subscale: Discomfort: Self-report rating scale - subscale reflecting expected alcohol-related relief from discomfort (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Discomfort - 30 Minutes | 30 minutes | Alcohol Craving Scale (ACS) Subscale: Discomfort: Self-report rating scale - subscale reflecting expected alcohol-related relief from discomfort (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes | 60 minutes | Alcohol Craving Scale (ACS) Subscale: Discomfort: Self-report rating scale - subscale reflecting expected alcohol-related relief from discomfort (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Discomfort - 120 Minutes | 120 minutes | Alcohol Craving Scale (ACS) Subscale: Discomfort: Self-report rating scale - subscale reflecting expected alcohol-related relief from discomfort (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - Baseline | Baseline | Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes Prior to Glycine Infusion | 60 minutes prior to Glycine infusion | Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 30 Minutes | 30 minutes | Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes | 60 minutes | Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) |
| Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 120 Minutes | 120 minutes | Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely) |
| Continuous Performance Task (CPT) - Distractibility A-Prime - 30 Minutes | 30 minutes | gordon diagnostic system is a continuous performance task (CPT) to measure distractibility - (A-Prime score range 0 minimum - 1 maximum - the higher number the better the performance) |
| Continuous Performance Task (CPT) - Vigilance - A-Prime Score 30 Minutes | 30 minutes | gordon diagnostic system is a continuous performance task (CPT) to measure Vigilance - (A-Prime score range 0 minimum - 1 maximum - The higher number the better the performance) |
| Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 1 | 60 minutes - Trial 1 | Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function. (Three immediate recall trials) (0 No words recalled - 12 all words recalled) |
| Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 2 | 60 minutes - Trial 2 | Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function. (Three immediate recall trials) (0 No words recalled - 12 all words recalled) |
| Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 3 | 60 minutes - Trial 3 | Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function. (Three immediate recall trials) (0 No words recalled - 12 all words recalled) |
| Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline | Baseline | Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol |
| Hopkins Verbal Learning Task - Delay Recall - 90 Minutes | 90 minutes | Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function. (delay recall - 30 minutes after Trials 1-3 were given) (0 No words recalled - 12 all words recalled) |
| Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion | 60 minutes prior to Glycine infusion | The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. |
| Number of Drinks Felt Consumed at 30 Minutes | 30 minutes | The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. |
| Number of Drinks Felt Consumed at 60 Minutes | 60 minutes | The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. |
| Number of Drinks Felt Consumed at 120 Minutes | 120 minutes | The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed. |
Countries
United States
Participant flow
Recruitment details
Alcoholic subjects were recruited from the Substance Abuse Treatment Program at VA Connecticut Healthcare Systems in West Haven, through advertisements in newspapers and postings in the community. Healthy subjects were recruited from the advertisements in newspapers and postings throughout the community.
Participants by arm
| Arm | Count |
|---|---|
| Alcoholic Subjects Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 70 yrs. who meet DSM IV criteria for alcohol dependence by structured clinical interview | 27 |
| Healthy Subjects Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 70 yrs who have been absence of a lifetime substance abuse diagnosis by the non-patient version of the SCID. | 30 |
| Total | 57 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 |
|---|---|---|---|
| Overall Study | Withdrawal by Subject | 7 | 8 |
Baseline characteristics
| Characteristic | Healthy Subjects | Alcoholic Subjects | Total |
|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical Between 18 and 65 years | 30 Participants | 27 Participants | 57 Participants |
| Age, Continuous | 31.9 years STANDARD_DEVIATION 10 | 43.6 years STANDARD_DEVIATION 9.5 | 37.9 years STANDARD_DEVIATION 0.17 |
| Gender Female | 7 Participants | 0 Participants | 7 Participants |
| Gender Male | 23 Participants | 27 Participants | 50 Participants |
| Region of Enrollment United States | 30 participants | 27 participants | 57 participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — |
| other Total, other adverse events | 0 / 27 | 0 / 30 |
| serious Total, serious adverse events | 0 / 27 | 0 / 30 |
Outcome results
Primary
Visual Analog Scales of Similarity to Alcohol 120 Minutes
Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Time frame: 120 minutes
Population: Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 120 Minutes | Glycine / Cycloserine | 0.43 units on a scale | Standard Deviation 1.08 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 120 Minutes | Glycine / Placebo | 0.3 units on a scale | Standard Deviation 0.98 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 120 Minutes | Placebo / Cycloserine | 0.57 units on a scale | Standard Deviation 0.87 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 120 Minutes | Placebo / Placebo | 0.10 units on a scale | Standard Deviation 0.3 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 120 Minutes | Placebo / Placebo | 0.33 units on a scale | Standard Deviation 1.44 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 120 Minutes | Glycine / Cycloserine | 0.41 units on a scale | Standard Deviation 1.14 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 120 Minutes | Placebo / Cycloserine | 0.29 units on a scale | Standard Deviation 0.62 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 120 Minutes | Glycine / Placebo | 0.09 units on a scale | Standard Deviation 0.29 |
Primary
Visual Analog Scales of Similarity to Alcohol 30 Minutes
Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Time frame: 30 minutes
Population: Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 30 Minutes | Glycine / Placebo | 0.60 units on a scale | Standard Deviation 1.14 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 30 Minutes | Glycine / Cycloserine | 0.57 units on a scale | Standard Deviation 1.17 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 30 Minutes | Placebo / Cycloserine | 1.05 units on a scale | Standard Deviation 1.56 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 30 Minutes | Placebo / Placebo | 0.43 units on a scale | Standard Deviation 0.98 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 30 Minutes | Placebo / Placebo | 0.13 units on a scale | Standard Deviation 0.34 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 30 Minutes | Glycine / Placebo | 0.71 units on a scale | Standard Deviation 1.45 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 30 Minutes | Placebo / Cycloserine | 1.21 units on a scale | Standard Deviation 2.13 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 30 Minutes | Glycine / Cycloserine | 1.81 units on a scale | Standard Deviation 1.89 |
Primary
Visual Analog Scales of Similarity to Alcohol 60 Minutes
Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Time frame: 60 minutes
Population: Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes | Glycine / Cycloserine | 0.67 units on a scale | Standard Deviation 1.494 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes | Glycine / Placebo | 0.75 units on a scale | Standard Deviation 1.52 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes | Placebo / Cycloserine | 0.81 units on a scale | Standard Deviation 1.21 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes | Placebo / Placebo | 0.24 units on a scale | Standard Deviation 0.54 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes | Placebo / Placebo | 0.13 units on a scale | Standard Deviation 0.45 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes | Glycine / Cycloserine | 1.81 units on a scale | Standard Deviation 1.72 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes | Placebo / Cycloserine | 1.46 units on a scale | Standard Deviation 2.17 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes | Glycine / Placebo | 0.70 units on a scale | Standard Deviation 1.43 |
Primary
Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion
Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Time frame: 60 minutes prior to Glycine infusion
Population: Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 0.77 units on a scale | Standard Deviation 1.77 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 0.65 units on a scale | Standard Deviation 1.27 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 0.48 units on a scale | Standard Deviation 0.87 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 0.43 units on a scale | Standard Deviation 0.93 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | .025 units on a scale | Standard Deviation 0.61 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 1.41 units on a scale | Standard Deviation 1.65 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 1.17 units on a scale | Standard Deviation 1.66 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 0.67 units on a scale | Standard Deviation 1.63 |
Primary
Visual Analog Scales of Similarity to Alcohol - Baseline
Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
Time frame: Baseline
Population: Visual Analog Scales of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol -7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol - Baseline | Glycine / Cycloserine | 0.18 units on a scale | Standard Deviation 0.5 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol - Baseline | Glycine / Placebo | 0.25 units on a scale | Standard Deviation 1.12 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol - Baseline | Placebo / Cycloserine | 0.10 units on a scale | Standard Deviation 0.3 |
| Alcoholic Subjects | Visual Analog Scales of Similarity to Alcohol - Baseline | Placebo / Placebo | 0.24 units on a scale | Standard Deviation 0.54 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol - Baseline | Placebo / Placebo | 0 units on a scale | Standard Deviation 0 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol - Baseline | Glycine / Cycloserine | 0.05 units on a scale | Standard Deviation 0.21 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol - Baseline | Placebo / Cycloserine | 0.04 units on a scale | Standard Deviation 0.2 |
| Healthy Subjects | Visual Analog Scales of Similarity to Alcohol - Baseline | Glycine / Placebo | 0.04 units on a scale | Standard Deviation 0.2 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 120 Minutes
Alcohol Craving Scale (ACS) Subscale: Desire to drink: Self-report rating scale used to measure desire to drink alcohol (0 No desire to drink alcohol - 100 Definitely desire to drink alcohol)
Time frame: 120 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 120 Minutes | Glycine / Cycloserine | 6.19 units on a scale | Standard Deviation 10.71 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 120 Minutes | Glycine / Placebo | 8 units on a scale | Standard Deviation 13.99 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 120 Minutes | Placebo / Cycloserine | 9.05 units on a scale | Standard Deviation 14.8 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 120 Minutes | Placebo / Placebo | 5.24 units on a scale | Standard Deviation 9.28 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 120 Minutes | Placebo / Placebo | 2.08 units on a scale | Standard Deviation 6.58 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 120 Minutes | Glycine / Cycloserine | 1.30 units on a scale | Standard Deviation 4.58 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 120 Minutes | Placebo / Cycloserine | 2.08 units on a scale | Standard Deviation 6.58 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 120 Minutes | Glycine / Placebo | 1.667 units on a scale | Standard Deviation 4.82 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Desire to Drink: - 30 Minutes
Alcohol Craving Scale (ACS) Subscale: Desire to drink: Self-report rating scale used to measure desire to drink alcohol (0 No desire to drink alcohol - 100 Definitely desire to drink alcohol)
Time frame: 30 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink: - 30 Minutes | Placebo / Cycloserine | 8 units on a scale | Standard Deviation 13.99 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink: - 30 Minutes | Glycine / Cycloserine | 9.05 units on a scale | Standard Deviation 19.21 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink: - 30 Minutes | Glycine / Placebo | 9 units on a scale | Standard Deviation 14.83 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink: - 30 Minutes | Placebo / Placebo | 5.71 units on a scale | Standard Deviation 10.28 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink: - 30 Minutes | Placebo / Placebo | 2.08 units on a scale | Standard Deviation 6.58 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink: - 30 Minutes | Placebo / Cycloserine | 2.5 units on a scale | Standard Deviation 7.37 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink: - 30 Minutes | Glycine / Placebo | 2.17 units on a scale | Standard Deviation 7.36 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink: - 30 Minutes | Glycine / Cycloserine | 1.82 units on a scale | Standard Deviation 6.65 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes
Alcohol Craving Scale (ACS) Subscale: Desire to drink: Self-report rating scale used to measure desire to drink alcohol (0 No desire to drink alcohol - 100 Definitely desire to drink alcohol)
Time frame: 60 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes | Glycine / Cycloserine | 6.5 units on a scale | Standard Deviation 11.37 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes | Glycine / Placebo | 9 units on a scale | Standard Deviation 15.18 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes | Placebo / Cycloserine | 10.48 units on a scale | Standard Deviation 16.88 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes | Placebo / Placebo | 5.71 units on a scale | Standard Deviation 9.78 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes | Placebo / Placebo | 2.08 units on a scale | Standard Deviation 5.88 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes | Glycine / Cycloserine | 1.82 units on a scale | Standard Deviation 6.65 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes | Placebo / Cycloserine | 1.67 units on a scale | Standard Deviation 6.37 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes | Glycine / Placebo | 2.17 units on a scale | Standard Deviation 7.36 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes Prior to Glycine Infusion
Alcohol Craving Scale (ACS) Subscale: Desire to drink: Self-report rating scale used to measure desire to drink alcohol (0 No desire to drink alcohol - 100 Definitely desire to drink alcohol)
Time frame: 60 minutes prior to Glycine infusion
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 7.27 units on a scale | Standard Deviation 10.77 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 8.5 units on a scale | Standard Deviation 14.24 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 6.67 units on a scale | Standard Deviation 11.97 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 4.76 units on a scale | Standard Deviation 8.14 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 1.25 units on a scale | Standard Deviation 4.48 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 2.61 units on a scale | Standard Deviation 7.52 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 3.04 units on a scale | Standard Deviation 8.76 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink - 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 1.67 units on a scale | Standard Deviation 6.37 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Desire to Drink- Baseline
Alcohol Craving Scale (ACS) Subscale: Desire to drink: Self-report rating scale used to measure desire to drink alcohol (0 No desire to drink alcohol - 100 Definitely desire to drink alcohol)
Time frame: Baseline
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink- Baseline | Glycine / Cycloserine | 7.62 units on a scale | Standard Deviation 12.21 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink- Baseline | Placebo / Cycloserine | 5 units on a scale | Standard Deviation 8.02 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink- Baseline | Glycine / Placebo | 9.5 units on a scale | Standard Deviation 17.01 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink- Baseline | Placebo / Placebo | 7.62 units on a scale | Standard Deviation 10.91 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink- Baseline | Placebo / Placebo | 0 units on a scale | Standard Deviation 0 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink- Baseline | Glycine / Cycloserine | 3.04 units on a scale | Standard Deviation 7.03 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink- Baseline | Glycine / Placebo | 2.5 units on a scale | Standard Deviation 7.37 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Desire to Drink- Baseline | Placebo / Cycloserine | 1.67 units on a scale | Standard Deviation 4.82 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Discomfort - 120 Minutes
Alcohol Craving Scale (ACS) Subscale: Discomfort: Self-report rating scale - subscale reflecting expected alcohol-related relief from discomfort (0 Not at all - 100 Definitely)
Time frame: 120 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 120 Minutes | Glycine / Cycloserine | 8.57 units on a scale | Standard Deviation 13.52 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 120 Minutes | Glycine / Placebo | 9.5 units on a scale | Standard Deviation 15.38 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 120 Minutes | Placebo / Cycloserine | 9.05 units on a scale | Standard Deviation 15.78 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 120 Minutes | Placebo / Placebo | 6.19 units on a scale | Standard Deviation 11.17 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 120 Minutes | Placebo / Placebo | 0.83 units on a scale | Standard Deviation 4.08 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 120 Minutes | Glycine / Cycloserine | 1.14 units on a scale | Standard Deviation 4.91 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 120 Minutes | Placebo / Cycloserine | 0.42 units on a scale | Standard Deviation 2.04 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 120 Minutes | Glycine / Placebo | 1.67 units on a scale | Standard Deviation 5.65 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Discomfort - 30 Minutes
Alcohol Craving Scale (ACS) Subscale: Discomfort: Self-report rating scale - subscale reflecting expected alcohol-related relief from discomfort (0 Not at all - 100 Definitely)
Time frame: 30 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 30 Minutes | Glycine / Cycloserine | 12.38 units on a scale | Standard Deviation 20.47 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 30 Minutes | Glycine / Placebo | 8.95 units on a scale | Standard Deviation 13.29 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 30 Minutes | Placebo / Cycloserine | 9.5 units on a scale | Standard Deviation 13.56 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 30 Minutes | Placebo / Placebo | 8.57 units on a scale | Standard Deviation 11.95 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 30 Minutes | Placebo / Placebo | 0.42 units on a scale | Standard Deviation 2.04 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 30 Minutes | Glycine / Cycloserine | 1.82 units on a scale | Standard Deviation 5.89 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 30 Minutes | Placebo / Cycloserine | 0.42 units on a scale | Standard Deviation 2.04 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 30 Minutes | Glycine / Placebo | 1.74 units on a scale | Standard Deviation 5.76 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes
Alcohol Craving Scale (ACS) Subscale: Discomfort: Self-report rating scale - subscale reflecting expected alcohol-related relief from discomfort (0 Not at all - 100 Definitely)
Time frame: 60 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes | Glycine / Cycloserine | 6.5 units on a scale | Standard Deviation 11.82 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes | Glycine / Placebo | 10.5 units on a scale | Standard Deviation 16.7 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes | Placebo / Cycloserine | 9.05 units on a scale | Standard Deviation 15.46 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes | Placebo / Placebo | 6.19 units on a scale | Standard Deviation 10.71 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes | Placebo / Placebo | 0.83 units on a scale | Standard Deviation 4.08 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes | Glycine / Cycloserine | 1.36 units on a scale | Standard Deviation 4.68 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes | Placebo / Cycloserine | 0.42 units on a scale | Standard Deviation 2.04 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes | Glycine / Placebo | 1.74 units on a scale | Standard Deviation 5.76 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes Prior to Glycine Infusion
Alcohol Craving Scale (ACS) Subscale: Discomfort: Self-report rating scale - subscale reflecting expected alcohol-related relief from discomfort (0 Not at all - 100 Definitely)
Time frame: 60 minutes prior to Glycine infusion
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 6.36 units on a scale | Standard Deviation 11.36 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 8.95 units on a scale | Standard Deviation 13.29 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 7.14 units on a scale | Standard Deviation 11.02 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 10.48 units on a scale | Standard Deviation 15.65 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 0.42 units on a scale | Standard Deviation 2.04 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 1.30 units on a scale | Standard Deviation 4.58 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 0.44 units on a scale | Standard Deviation 2.09 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 1.25 units on a scale | Standard Deviation 4.48 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Discomfort - Baseline
Alcohol Craving Scale (ACS) Subscale: Discomfort: Self-report rating scale - subscale reflecting expected alcohol-related relief from discomfort (0 Not at all - 100 Definitely)
Time frame: Baseline
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - Baseline | Glycine / Cycloserine | 8.1 units on a scale | Standard Deviation 15.04 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - Baseline | Glycine / Placebo | 12.5 units on a scale | Standard Deviation 18.6 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - Baseline | Placebo / Cycloserine | 7.73 units on a scale | Standard Deviation 13.78 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - Baseline | Placebo / Placebo | 8.10 units on a scale | Standard Deviation 13.65 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - Baseline | Placebo / Placebo | 0.42 units on a scale | Standard Deviation 2.04 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - Baseline | Glycine / Cycloserine | 2.61 units on a scale | Standard Deviation 6.19 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - Baseline | Placebo / Cycloserine | 0.42 units on a scale | Standard Deviation 2.04 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Discomfort - Baseline | Glycine / Placebo | 1.67 units on a scale | Standard Deviation 5.65 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 120 Minutes
Alcohol Craving Scale (ACS) Subscale: Mood improvement : Self-report rating scale used to measure expected alcohol-related mood improvement (0 Not at all - 100 Definitely)
Time frame: 120 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 120 Minutes | Glycine / Cycloserine | 6.19 units on a scale | Standard Deviation 11.61 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 120 Minutes | Glycine / Placebo | 7 units on a scale | Standard Deviation 11.74 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 120 Minutes | Placebo / Cycloserine | 8.57 units on a scale | Standard Deviation 14.24 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 120 Minutes | Placebo / Placebo | 7.62 units on a scale | Standard Deviation 14.11 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 120 Minutes | Placebo / Placebo | 0.42 units on a scale | Standard Deviation 2.04 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 120 Minutes | Glycine / Cycloserine | 0.87 units on a scale | Standard Deviation 2.88 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 120 Minutes | Placebo / Cycloserine | 0.42 units on a scale | Standard Deviation 2.04 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 120 Minutes | Glycine / Placebo | 0.83 units on a scale | Standard Deviation 4.08 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 30 Minutes
Alcohol Craving Scale (ACS) Subscale: Mood improvement : Self-report rating scale used to measure expected alcohol-related mood improvement (0 Not at all - 100 Definitely)
Time frame: 30 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 30 Minutes | Glycine / Cycloserine | 11.43 units on a scale | Standard Deviation 22.2 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 30 Minutes | Glycine / Placebo | 8 units on a scale | Standard Deviation 12.81 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 30 Minutes | Placebo / Cycloserine | 10.5 units on a scale | Standard Deviation 14.68 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 30 Minutes | Placebo / Placebo | 6.67 units on a scale | Standard Deviation 10.17 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 30 Minutes | Placebo / Placebo | 0.42 units on a scale | Standard Deviation 2.04 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 30 Minutes | Glycine / Cycloserine | 0.91 units on a scale | Standard Deviation 4.26 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 30 Minutes | Placebo / Cycloserine | 0.42 units on a scale | Standard Deviation 2.04 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 30 Minutes | Glycine / Placebo | 0.87 units on a scale | Standard Deviation 4.17 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes
Alcohol Craving Scale (ACS) Subscale: Mood improvement : Self-report rating scale used to measure expected alcohol-related mood improvement (0 Not at all - 100 Definitely)
Time frame: 60 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes | Glycine / Cycloserine | 5.5 units on a scale | Standard Deviation 9.45 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes | Glycine / Placebo | 8.5 units on a scale | Standard Deviation 13.87 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes | Placebo / Cycloserine | 8.1 units on a scale | Standard Deviation 12.5 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes | Placebo / Placebo | 6.67 units on a scale | Standard Deviation 11.97 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes | Placebo / Placebo | 0.83 units on a scale | Standard Deviation 4.08 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes | Glycine / Cycloserine | 0.46 units on a scale | Standard Deviation 2.13 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes | Placebo / Cycloserine | 0.83 units on a scale | Standard Deviation 2.82 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes | Glycine / Placebo | 0.87 units on a scale | Standard Deviation 4.17 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes Prior to Glycine Infusion
Alcohol Craving Scale (ACS) Subscale: Mood improvement : Self-report rating scale used to measure expected alcohol-related mood improvement (0 Not at all - 100 Definitely)
Time frame: 60 minutes prior to Glycine infusion
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 7.73 units on a scale | Standard Deviation 14.78 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 8 units on a scale | Standard Deviation 11.97 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 7.62 units on a scale | Standard Deviation 11.79 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 6.19 units on a scale | Standard Deviation 10.71 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 0.42 units on a scale | Standard Deviation 2.04 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 0.87 units on a scale | Standard Deviation 2.88 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 1.30 units on a scale | Standard Deviation 4.58 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 0.83 units on a scale | Standard Deviation 4.08 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Mood Improvement - Baseline
Alcohol Craving Scale (ACS) Subscale: Mood improvement : Self-report rating scale used to measure expected alcohol-related mood improvement (0 Not at all - 100 Definitely)
Time frame: Baseline
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - Baseline | Glycine / Cycloserine | 6.67 units on a scale | Standard Deviation 11.55 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - Baseline | Glycine / Placebo | 10.5 units on a scale | Standard Deviation 16.69 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - Baseline | Placebo / Cycloserine | 6.82 units on a scale | Standard Deviation 12.87 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - Baseline | Placebo / Placebo | 8.10 units on a scale | Standard Deviation 13.65 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - Baseline | Placebo / Placebo | 0 units on a scale | Standard Deviation 0 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - Baseline | Glycine / Cycloserine | 1.74 units on a scale | Standard Deviation 4.91 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - Baseline | Placebo / Cycloserine | 0.42 units on a scale | Standard Deviation 2.01 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Mood Improvement - Baseline | Glycine / Placebo | 0.42 units on a scale | Standard Deviation 2.04 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 120 Minutes
Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely)
Time frame: 120 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 120 Minutes | Glycine / Cycloserine | 34.29 units on a scale | Standard Deviation 40.94 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 120 Minutes | Glycine / Placebo | 33.5 units on a scale | Standard Deviation 42.83 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 120 Minutes | Placebo / Cycloserine | 30.48 units on a scale | Standard Deviation 39.05 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 120 Minutes | Placebo / Placebo | 36.67 units on a scale | Standard Deviation 40.17 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 120 Minutes | Placebo / Placebo | 99.17 units on a scale | Standard Deviation 4.08 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 120 Minutes | Glycine / Cycloserine | 98.26 units on a scale | Standard Deviation 4.91 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 120 Minutes | Placebo / Cycloserine | 99.17 units on a scale | Standard Deviation 4.08 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 120 Minutes | Glycine / Placebo | 99.17 units on a scale | Standard Deviation 4.08 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 30 Minutes
Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely)
Time frame: 30 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 30 Minutes | Glycine / Cycloserine | 32.86 units on a scale | Standard Deviation 40.27 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 30 Minutes | Glycine / Placebo | 36 units on a scale | Standard Deviation 40.18 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 30 Minutes | Placebo / Cycloserine | 36.5 units on a scale | Standard Deviation 40.56 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 30 Minutes | Placebo / Placebo | 36.67 units on a scale | Standard Deviation 37.59 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 30 Minutes | Placebo / Placebo | 99.17 units on a scale | Standard Deviation 4.08 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 30 Minutes | Glycine / Cycloserine | 99.1 units on a scale | Standard Deviation 4.26 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 30 Minutes | Placebo / Cycloserine | 99.17 units on a scale | Standard Deviation 4.08 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 30 Minutes | Glycine / Placebo | 98.70 units on a scale | Standard Deviation 6.26 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes
Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely)
Time frame: 60 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes | Glycine / Cycloserine | 34 units on a scale | Standard Deviation 42.23 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes | Glycine / Placebo | 39.5 units on a scale | Standard Deviation 43.34 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes | Placebo / Cycloserine | 25.71 units on a scale | Standard Deviation 35.3 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes | Placebo / Placebo | 37.14 units on a scale | Standard Deviation 40.52 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes | Placebo / Placebo | 99.17 units on a scale | Standard Deviation 4.08 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes | Glycine / Cycloserine | 99.1 units on a scale | Standard Deviation 4.26 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes | Placebo / Cycloserine | 99.17 units on a scale | Standard Deviation 4.08 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes | Glycine / Placebo | 99.13 units on a scale | Standard Deviation 4.17 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes Prior to Glycine Infusion
Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely)
Time frame: 60 minutes prior to Glycine infusion
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 30.46 units on a scale | Standard Deviation 37.48 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 40.5 units on a scale | Standard Deviation 42.49 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 36.67 units on a scale | Standard Deviation 41.51 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 42.86 units on a scale | Standard Deviation 42.33 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 99.17 units on a scale | Standard Deviation 4.08 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 98.26 units on a scale | Standard Deviation 4.91 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 99.13 units on a scale | Standard Deviation 4.17 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 95 units on a scale | Standard Deviation 20.64 |
Secondary
Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - Baseline
Alcohol Craving Scale (ACS) Subscale: Self-report rating scale used to measure reduced control of alcohol (0 Not at all - 100 Definitely)
Time frame: Baseline
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - Baseline | Glycine / Cycloserine | 29.05 units on a scale | Standard Deviation 36.59 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - Baseline | Glycine / Placebo | 35.5 units on a scale | Standard Deviation 40.32 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - Baseline | Placebo / Cycloserine | 42.27 units on a scale | Standard Deviation 42.64 |
| Alcoholic Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - Baseline | Placebo / Placebo | 41.43 units on a scale | Standard Deviation 40.29 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - Baseline | Placebo / Placebo | 98.75 units on a scale | Standard Deviation 4.48 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - Baseline | Glycine / Cycloserine | 93.48 units on a scale | Standard Deviation 21.24 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - Baseline | Placebo / Cycloserine | 99.17 units on a scale | Standard Deviation 4.08 |
| Healthy Subjects | Alcohol Craving Scale (ACS) Subscale: Reduced Control of Alcohol Use - Baseline | Glycine / Placebo | 94.58 units on a scale | Standard Deviation 20.64 |
Secondary
Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 120 Minutes
Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol
Time frame: 120 minutes
Population: Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 120 Minutes | Glycine / Cycloserine | 3.57 units on a scale | Standard Deviation 7.02 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 120 Minutes | Glycine / Placebo | 4.35 units on a scale | Standard Deviation 8.56 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 120 Minutes | Placebo / Cycloserine | 4 units on a scale | Standard Deviation 7.36 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 120 Minutes | Placebo / Placebo | 3.71 units on a scale | Standard Deviation 7.72 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 120 Minutes | Placebo / Placebo | 1.25 units on a scale | Standard Deviation 2.82 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 120 Minutes | Glycine / Cycloserine | 4.13 units on a scale | Standard Deviation 7.21 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 120 Minutes | Placebo / Cycloserine | 3.04 units on a scale | Standard Deviation 4.69 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 120 Minutes | Glycine / Placebo | 1.67 units on a scale | Standard Deviation 3.31 |
Secondary
Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 30 Minutes
Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol
Time frame: 30 minutes
Population: Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 30 Minutes | Glycine / Cycloserine | 7.14 units on a scale | Standard Deviation 12.01 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 30 Minutes | Glycine / Placebo | 5.8 units on a scale | Standard Deviation 10.56 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 30 Minutes | Placebo / Cycloserine | 5.2 units on a scale | Standard Deviation 8.45 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 30 Minutes | Placebo / Placebo | 4.62 units on a scale | Standard Deviation 8.23 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 30 Minutes | Placebo / Placebo | 3.58 units on a scale | Standard Deviation 4.83 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 30 Minutes | Glycine / Cycloserine | 10.05 units on a scale | Standard Deviation 10.06 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 30 Minutes | Placebo / Cycloserine | 7.04 units on a scale | Standard Deviation 10.66 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 30 Minutes | Glycine / Placebo | 5.87 units on a scale | Standard Deviation 7.95 |
Secondary
Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 60 Minutes
Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol
Time frame: 60 minutes
Population: Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 60 Minutes | Glycine / Cycloserine | 5.29 units on a scale | Standard Deviation 8.49 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 60 Minutes | Glycine / Placebo | 5.65 units on a scale | Standard Deviation 11.62 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 60 Minutes | Placebo / Cycloserine | 8.48 units on a scale | Standard Deviation 11.96 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 60 Minutes | Placebo / Placebo | 4.14 units on a scale | Standard Deviation 7.4 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 60 Minutes | Placebo / Placebo | 2.54 units on a scale | Standard Deviation 4.92 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 60 Minutes | Glycine / Cycloserine | 9.64 units on a scale | Standard Deviation 10.98 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 60 Minutes | Placebo / Cycloserine | 8.54 units on a scale | Standard Deviation 11.84 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - 60 Minutes | Glycine / Placebo | 5.83 units on a scale | Standard Deviation 8.87 |
Secondary
Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation 60 Minutes Prior to Glycine Infusion
Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol
Time frame: 60 minutes prior to Glycine infusion
Population: Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 6.23 units on a scale | Standard Deviation 10.32 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 6.6 units on a scale | Standard Deviation 9.68 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 7.24 units on a scale | Standard Deviation 11.05 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 4.57 units on a scale | Standard Deviation 8.64 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 3.67 units on a scale | Standard Deviation 5.37 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 7.39 units on a scale | Standard Deviation 6.97 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 6.25 units on a scale | Standard Deviation 7.88 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 3.79 units on a scale | Standard Deviation 4.72 |
Secondary
Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline
Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol
Time frame: Baseline
Population: Self-report rating scale used to measure the sedative effects (0 not at all sedated - 70 extremely sedated) of alcohol
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline | Glycine / Cycloserine | 3.41 units on a scale | Standard Deviation 5.76 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline | Glycine / Placebo | 3.3 units on a scale | Standard Deviation 6.51 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline | Placebo / Cycloserine | 3.57 units on a scale | Standard Deviation 6.71 |
| Alcoholic Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline | Placebo / Placebo | 5 units on a scale | Standard Deviation 9.2 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline | Placebo / Placebo | 1.88 units on a scale | Standard Deviation 3.58 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline | Glycine / Cycloserine | 1.91 units on a scale | Standard Deviation 3.19 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline | Placebo / Cycloserine | 1.83 units on a scale | Standard Deviation 3.38 |
| Healthy Subjects | Biphasic Alcohol Effects Scale (BAES) Subscale Sedation - Baseline | Glycine / Placebo | 2.75 units on a scale | Standard Deviation 3.77 |
Secondary
Continuous Performance Task (CPT) - Distractibility A-Prime - 30 Minutes
gordon diagnostic system is a continuous performance task (CPT) to measure distractibility - (A-Prime score range 0 minimum - 1 maximum - the higher number the better the performance)
Time frame: 30 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Continuous Performance Task (CPT) - Distractibility A-Prime - 30 Minutes | Glycine / Cycloserine | 0.93 units on a scale | Standard Deviation 0.14 |
| Alcoholic Subjects | Continuous Performance Task (CPT) - Distractibility A-Prime - 30 Minutes | Glycine / Placebo | 0.97 units on a scale | Standard Deviation 0.05 |
| Alcoholic Subjects | Continuous Performance Task (CPT) - Distractibility A-Prime - 30 Minutes | Placebo / Cycloserine | 0.90 units on a scale | Standard Deviation 0.15 |
| Alcoholic Subjects | Continuous Performance Task (CPT) - Distractibility A-Prime - 30 Minutes | Placebo / Placebo | 0.96 units on a scale | Standard Deviation 0.05 |
| Healthy Subjects | Continuous Performance Task (CPT) - Distractibility A-Prime - 30 Minutes | Placebo / Placebo | 0.1 units on a scale | Standard Deviation 0.01 |
| Healthy Subjects | Continuous Performance Task (CPT) - Distractibility A-Prime - 30 Minutes | Glycine / Cycloserine | 0.1 units on a scale | Standard Deviation 0.01 |
| Healthy Subjects | Continuous Performance Task (CPT) - Distractibility A-Prime - 30 Minutes | Placebo / Cycloserine | 0.1 units on a scale | Standard Deviation 0.01 |
| Healthy Subjects | Continuous Performance Task (CPT) - Distractibility A-Prime - 30 Minutes | Glycine / Placebo | 0.1 units on a scale | Standard Deviation 0.01 |
Secondary
Continuous Performance Task (CPT) - Vigilance - A-Prime Score 30 Minutes
gordon diagnostic system is a continuous performance task (CPT) to measure Vigilance - (A-Prime score range 0 minimum - 1 maximum - The higher number the better the performance)
Time frame: 30 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Continuous Performance Task (CPT) - Vigilance - A-Prime Score 30 Minutes | Glycine / Cycloserine | 0.98 units on a scale | Standard Deviation 0.03 |
| Alcoholic Subjects | Continuous Performance Task (CPT) - Vigilance - A-Prime Score 30 Minutes | Glycine / Placebo | 0.1 units on a scale | Standard Deviation 0.01 |
| Alcoholic Subjects | Continuous Performance Task (CPT) - Vigilance - A-Prime Score 30 Minutes | Placebo / Cycloserine | 0.1 units on a scale | Standard Deviation 0.02 |
| Alcoholic Subjects | Continuous Performance Task (CPT) - Vigilance - A-Prime Score 30 Minutes | Placebo / Placebo | 0.99 units on a scale | Standard Deviation 0.02 |
| Healthy Subjects | Continuous Performance Task (CPT) - Vigilance - A-Prime Score 30 Minutes | Placebo / Placebo | 0.1 units on a scale | Standard Deviation 0 |
| Healthy Subjects | Continuous Performance Task (CPT) - Vigilance - A-Prime Score 30 Minutes | Glycine / Cycloserine | 0.1 units on a scale | Standard Deviation 0.01 |
| Healthy Subjects | Continuous Performance Task (CPT) - Vigilance - A-Prime Score 30 Minutes | Placebo / Cycloserine | 0.1 units on a scale | Standard Deviation 0.01 |
| Healthy Subjects | Continuous Performance Task (CPT) - Vigilance - A-Prime Score 30 Minutes | Glycine / Placebo | 0.1 units on a scale | Standard Deviation 0.02 |
Secondary
Hopkins Verbal Learning Task - Delay Recall - 90 Minutes
Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function. (delay recall - 30 minutes after Trials 1-3 were given) (0 No words recalled - 12 all words recalled)
Time frame: 90 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Hopkins Verbal Learning Task - Delay Recall - 90 Minutes | Glycine / Cycloserine | 5.1 units on a scale | Standard Deviation 3.43 |
| Alcoholic Subjects | Hopkins Verbal Learning Task - Delay Recall - 90 Minutes | Glycine / Placebo | 7.75 units on a scale | Standard Deviation 2.4 |
| Alcoholic Subjects | Hopkins Verbal Learning Task - Delay Recall - 90 Minutes | Placebo / Cycloserine | 6.29 units on a scale | Standard Deviation 2.78 |
| Alcoholic Subjects | Hopkins Verbal Learning Task - Delay Recall - 90 Minutes | Placebo / Placebo | 8.25 units on a scale | Standard Deviation 2.43 |
| Healthy Subjects | Hopkins Verbal Learning Task - Delay Recall - 90 Minutes | Placebo / Placebo | 11.38 units on a scale | Standard Deviation 1.28 |
| Healthy Subjects | Hopkins Verbal Learning Task - Delay Recall - 90 Minutes | Glycine / Cycloserine | 9.7 units on a scale | Standard Deviation 2.44 |
| Healthy Subjects | Hopkins Verbal Learning Task - Delay Recall - 90 Minutes | Placebo / Cycloserine | 10.21 units on a scale | Standard Deviation 1.74 |
| Healthy Subjects | Hopkins Verbal Learning Task - Delay Recall - 90 Minutes | Glycine / Placebo | 10.87 units on a scale | Standard Deviation 1.39 |
Secondary
Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 1
Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function. (Three immediate recall trials) (0 No words recalled - 12 all words recalled)
Time frame: 60 minutes - Trial 1
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 1 | Glycine / Cycloserine | 5.29 units on a scale | Standard Deviation 1.93 |
| Alcoholic Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 1 | Glycine / Placebo | 6.05 units on a scale | Standard Deviation 1.91 |
| Alcoholic Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 1 | Placebo / Cycloserine | 5.48 units on a scale | Standard Deviation 1.12 |
| Alcoholic Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 1 | Placebo / Placebo | 5.95 units on a scale | Standard Deviation 1.66 |
| Healthy Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 1 | Placebo / Placebo | 8.2 units on a scale | Standard Deviation 1.56 |
| Healthy Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 1 | Glycine / Cycloserine | 7.09 units on a scale | Standard Deviation 1.81 |
| Healthy Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 1 | Placebo / Cycloserine | 7.75 units on a scale | Standard Deviation 1.82 |
| Healthy Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 1 | Glycine / Placebo | 8.52 units on a scale | Standard Deviation 1.95 |
Secondary
Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 2
Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function. (Three immediate recall trials) (0 No words recalled - 12 all words recalled)
Time frame: 60 minutes - Trial 2
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 2 | Glycine / Cycloserine | 7.67 units on a scale | Standard Deviation 2.08 |
| Alcoholic Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 2 | Glycine / Placebo | 8.45 units on a scale | Standard Deviation 1.96 |
| Alcoholic Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 2 | Placebo / Cycloserine | 7.1 units on a scale | Standard Deviation 1.67 |
| Alcoholic Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 2 | Placebo / Placebo | 8.67 units on a scale | Standard Deviation 1.83 |
| Healthy Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 2 | Placebo / Placebo | 10.96 units on a scale | Standard Deviation 1.37 |
| Healthy Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 2 | Glycine / Cycloserine | 10.09 units on a scale | Standard Deviation 1.88 |
| Healthy Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 2 | Placebo / Cycloserine | 10.5 units on a scale | Standard Deviation 1.18 |
| Healthy Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 2 | Glycine / Placebo | 11.09 units on a scale | Standard Deviation 1.2 |
Secondary
Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 3
Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function. (Three immediate recall trials) (0 No words recalled - 12 all words recalled)
Time frame: 60 minutes - Trial 3
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 3 | Glycine / Cycloserine | 8 units on a scale | Standard Deviation 2.47 |
| Alcoholic Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 3 | Glycine / Placebo | 9.2 units on a scale | Standard Deviation 2.14 |
| Alcoholic Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 3 | Placebo / Cycloserine | 8.48 units on a scale | Standard Deviation 2.02 |
| Alcoholic Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 3 | Placebo / Placebo | 9.24 units on a scale | Standard Deviation 1.64 |
| Healthy Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 3 | Placebo / Placebo | 11.67 units on a scale | Standard Deviation 0.76 |
| Healthy Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 3 | Glycine / Cycloserine | 10.57 units on a scale | Standard Deviation 1.59 |
| Healthy Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 3 | Placebo / Cycloserine | 11.17 units on a scale | Standard Deviation 0.82 |
| Healthy Subjects | Hopkins Verbal Learning Task - Immediate Recall - 60 Minutes - Trial 3 | Glycine / Placebo | 11.48 units on a scale | Standard Deviation 0.85 |
Secondary
Number of Drinks Felt Consumed at 120 Minutes
The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed.
Time frame: 120 minutes
Population: The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Number of Drinks Felt Consumed at 120 Minutes | Glycine / Cycloserine | 0 Number of Drinks Felt Consumed | Standard Deviation 0 |
| Alcoholic Subjects | Number of Drinks Felt Consumed at 120 Minutes | Glycine / Placebo | 0.1 Number of Drinks Felt Consumed | Standard Deviation 0.45 |
| Alcoholic Subjects | Number of Drinks Felt Consumed at 120 Minutes | Placebo / Cycloserine | 0.05 Number of Drinks Felt Consumed | Standard Deviation 0.22 |
| Alcoholic Subjects | Number of Drinks Felt Consumed at 120 Minutes | Placebo / Placebo | 0 Number of Drinks Felt Consumed | Standard Deviation 0 |
| Healthy Subjects | Number of Drinks Felt Consumed at 120 Minutes | Placebo / Placebo | 0.04 Number of Drinks Felt Consumed | Standard Deviation 0.2 |
| Healthy Subjects | Number of Drinks Felt Consumed at 120 Minutes | Glycine / Cycloserine | 0.13 Number of Drinks Felt Consumed | Standard Deviation 0.34 |
| Healthy Subjects | Number of Drinks Felt Consumed at 120 Minutes | Placebo / Cycloserine | 0 Number of Drinks Felt Consumed | Standard Deviation 0 |
| Healthy Subjects | Number of Drinks Felt Consumed at 120 Minutes | Glycine / Placebo | 0.21 Number of Drinks Felt Consumed | Standard Deviation 0.83 |
Secondary
Number of Drinks Felt Consumed at 30 Minutes
The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed.
Time frame: 30 minutes
Population: The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Number of Drinks Felt Consumed at 30 Minutes | Glycine / Cycloserine | 0.38 Number of Drinks Felt Consumed | Standard Deviation 1.32 |
| Alcoholic Subjects | Number of Drinks Felt Consumed at 30 Minutes | Glycine / Placebo | 0.20 Number of Drinks Felt Consumed | Standard Deviation 0.62 |
| Alcoholic Subjects | Number of Drinks Felt Consumed at 30 Minutes | Placebo / Cycloserine | 0.38 Number of Drinks Felt Consumed | Standard Deviation 0.74 |
| Alcoholic Subjects | Number of Drinks Felt Consumed at 30 Minutes | Placebo / Placebo | 0.24 Number of Drinks Felt Consumed | Standard Deviation 0.77 |
| Healthy Subjects | Number of Drinks Felt Consumed at 30 Minutes | Placebo / Placebo | 0.04 Number of Drinks Felt Consumed | Standard Deviation 0.2 |
| Healthy Subjects | Number of Drinks Felt Consumed at 30 Minutes | Glycine / Cycloserine | 0.68 Number of Drinks Felt Consumed | Standard Deviation 1 |
| Healthy Subjects | Number of Drinks Felt Consumed at 30 Minutes | Placebo / Cycloserine | 0.38 Number of Drinks Felt Consumed | Standard Deviation 1.1 |
| Healthy Subjects | Number of Drinks Felt Consumed at 30 Minutes | Glycine / Placebo | 0.13 Number of Drinks Felt Consumed | Standard Deviation 0.34 |
Secondary
Number of Drinks Felt Consumed at 60 Minutes
The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed.
Time frame: 60 minutes
Population: The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Number of Drinks Felt Consumed at 60 Minutes | Glycine / Cycloserine | 0.05 Number of Drinks Felt Consumed | Standard Deviation 0.22 |
| Alcoholic Subjects | Number of Drinks Felt Consumed at 60 Minutes | Glycine / Placebo | 0.5 Number of Drinks Felt Consumed | Standard Deviation 1.1 |
| Alcoholic Subjects | Number of Drinks Felt Consumed at 60 Minutes | Placebo / Cycloserine | 0.86 Number of Drinks Felt Consumed | Standard Deviation 1.65 |
| Alcoholic Subjects | Number of Drinks Felt Consumed at 60 Minutes | Placebo / Placebo | 0.05 Number of Drinks Felt Consumed | Standard Deviation 0.22 |
| Healthy Subjects | Number of Drinks Felt Consumed at 60 Minutes | Placebo / Placebo | 0.2 Number of Drinks Felt Consumed | Standard Deviation 0.58 |
| Healthy Subjects | Number of Drinks Felt Consumed at 60 Minutes | Glycine / Cycloserine | 1.24 Number of Drinks Felt Consumed | Standard Deviation 1.73 |
| Healthy Subjects | Number of Drinks Felt Consumed at 60 Minutes | Placebo / Cycloserine | 0.83 Number of Drinks Felt Consumed | Standard Deviation 1.47 |
| Healthy Subjects | Number of Drinks Felt Consumed at 60 Minutes | Glycine / Placebo | 0.4 Number of Drinks Felt Consumed | Standard Deviation 0.9 |
Secondary
Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion
The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed.
Time frame: 60 minutes prior to Glycine infusion
Population: The Number of Drinks Scale asks subjects to report on the number of alcoholic drinks they felt they had consumed.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 0.50 drinks felt consumed | Standard Deviation 1.34 |
| Alcoholic Subjects | Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 0.30 drinks felt consumed | Standard Deviation 0.73 |
| Alcoholic Subjects | Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 0.24 drinks felt consumed | Standard Deviation 0.54 |
| Alcoholic Subjects | Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 0.05 drinks felt consumed | Standard Deviation 0.22 |
| Healthy Subjects | Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 0.22 drinks felt consumed | Standard Deviation 0.52 |
| Healthy Subjects | Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 0.70 drinks felt consumed | Standard Deviation 1.4 |
| Healthy Subjects | Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 0.75 drinks felt consumed | Standard Deviation 1.03 |
| Healthy Subjects | Number of Drinks Felt Consumed at 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 0.25 drinks felt consumed | Standard Deviation 0.61 |
Secondary
Visual Analog Scales (VAS) - 120 Minutes
Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely)
Time frame: 120 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Visual Analog Scales (VAS) - 120 Minutes | Glycine / Cycloserine | 0.8 units on a scale | Standard Deviation 1.54 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - 120 Minutes | Glycine / Placebo | 0.55 units on a scale | Standard Deviation 1.05 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - 120 Minutes | Placebo / Cycloserine | 0.76 units on a scale | Standard Deviation 1.61 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - 120 Minutes | Placebo / Placebo | 0.24 units on a scale | Standard Deviation 0.54 |
| Healthy Subjects | Visual Analog Scales (VAS) - 120 Minutes | Placebo / Placebo | 0.25 units on a scale | Standard Deviation 0.9 |
| Healthy Subjects | Visual Analog Scales (VAS) - 120 Minutes | Glycine / Cycloserine | 0.35 units on a scale | Standard Deviation 1.11 |
| Healthy Subjects | Visual Analog Scales (VAS) - 120 Minutes | Placebo / Cycloserine | 0.29 units on a scale | Standard Deviation 0.91 |
| Healthy Subjects | Visual Analog Scales (VAS) - 120 Minutes | Glycine / Placebo | 0.21 units on a scale | Standard Deviation 0.83 |
Secondary
Visual Analog Scales (VAS) - 30 Minutes
Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely)
Time frame: 30 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Visual Analog Scales (VAS) - 30 Minutes | Glycine / Cycloserine | 0.48 units on a scale | Standard Deviation 0.98 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - 30 Minutes | Glycine / Placebo | 0.65 units on a scale | Standard Deviation 1.09 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - 30 Minutes | Placebo / Cycloserine | 0.48 units on a scale | Standard Deviation 0.93 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - 30 Minutes | Placebo / Placebo | 0.52 units on a scale | Standard Deviation 1.03 |
| Healthy Subjects | Visual Analog Scales (VAS) - 30 Minutes | Placebo / Placebo | 0.25 units on a scale | Standard Deviation 0.9 |
| Healthy Subjects | Visual Analog Scales (VAS) - 30 Minutes | Glycine / Cycloserine | 1.05 units on a scale | Standard Deviation 1.73 |
| Healthy Subjects | Visual Analog Scales (VAS) - 30 Minutes | Placebo / Cycloserine | 0.79 units on a scale | Standard Deviation 1.56 |
| Healthy Subjects | Visual Analog Scales (VAS) - 30 Minutes | Glycine / Placebo | 0.30 units on a scale | Standard Deviation 0.7 |
Secondary
Visual Analog Scales (VAS) - 60 Minutes
Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely)
Time frame: 60 minutes
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Visual Analog Scales (VAS) - 60 Minutes | Glycine / Cycloserine | 0.52 units on a scale | Standard Deviation 1.37 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - 60 Minutes | Glycine / Placebo | 0.8 units on a scale | Standard Deviation 1.58 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - 60 Minutes | Placebo / Cycloserine | 0.6 units on a scale | Standard Deviation 0.99 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - 60 Minutes | Placebo / Placebo | 0.19 units on a scale | Standard Deviation 0.4 |
| Healthy Subjects | Visual Analog Scales (VAS) - 60 Minutes | Placebo / Placebo | 0.17 units on a scale | Standard Deviation 0.82 |
| Healthy Subjects | Visual Analog Scales (VAS) - 60 Minutes | Glycine / Cycloserine | 0.91 units on a scale | Standard Deviation 1.41 |
| Healthy Subjects | Visual Analog Scales (VAS) - 60 Minutes | Placebo / Cycloserine | 0.71 units on a scale | Standard Deviation 1.49 |
| Healthy Subjects | Visual Analog Scales (VAS) - 60 Minutes | Glycine / Placebo | 0.22 units on a scale | Standard Deviation 0.67 |
Secondary
Visual Analog Scales (VAS) - 60 Minutes Prior to Glycine Infusion
Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely)
Time frame: 60 minutes prior to Glycine infusion
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Visual Analog Scales (VAS) - 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 0.64 units on a scale | Standard Deviation 1.22 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 0.68 units on a scale | Standard Deviation 1.2 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 0.48 units on a scale | Standard Deviation 1.08 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 0.38 units on a scale | Standard Deviation 0.97 |
| Healthy Subjects | Visual Analog Scales (VAS) - 60 Minutes Prior to Glycine Infusion | Placebo / Placebo | 0.61 units on a scale | Standard Deviation 1.31 |
| Healthy Subjects | Visual Analog Scales (VAS) - 60 Minutes Prior to Glycine Infusion | Glycine / Cycloserine | 0.82 units on a scale | Standard Deviation 1.44 |
| Healthy Subjects | Visual Analog Scales (VAS) - 60 Minutes Prior to Glycine Infusion | Placebo / Cycloserine | 0.96 units on a scale | Standard Deviation 1.64 |
| Healthy Subjects | Visual Analog Scales (VAS) - 60 Minutes Prior to Glycine Infusion | Glycine / Placebo | 0.33 units on a scale | Standard Deviation 0.92 |
Secondary
Visual Analog Scales (VAS) - Baseline
Visual Analog Scales (VAS): Self-report rating scale used to measure high (0 not at all - 7 extremely)
Time frame: Baseline
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Alcoholic Subjects | Visual Analog Scales (VAS) - Baseline | Glycine / Cycloserine | 0.32 units on a scale | Standard Deviation 0.78 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - Baseline | Glycine / Placebo | 0.5 units on a scale | Standard Deviation 1.4 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - Baseline | Placebo / Cycloserine | 0.76 units on a scale | Standard Deviation 1.64 |
| Alcoholic Subjects | Visual Analog Scales (VAS) - Baseline | Placebo / Placebo | 0.48 units on a scale | Standard Deviation 0.98 |
| Healthy Subjects | Visual Analog Scales (VAS) - Baseline | Placebo / Placebo | 0.25 units on a scale | Standard Deviation 0.9 |
| Healthy Subjects | Visual Analog Scales (VAS) - Baseline | Glycine / Cycloserine | 0.22 units on a scale | Standard Deviation 0.85 |
| Healthy Subjects | Visual Analog Scales (VAS) - Baseline | Placebo / Cycloserine | 0.25 units on a scale | Standard Deviation 0.9 |
| Healthy Subjects | Visual Analog Scales (VAS) - Baseline | Glycine / Placebo | 0.22 units on a scale | Standard Deviation 0.85 |