Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy

Effect of Acetazolamide in Prevention of Contrast Nephropathy

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00634491

Enrollment

240

Registered

2008-03-13

Start date

2007-09-30

Completion date

2008-02-29

Last updated

2008-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Contrast Induced Nephropathy

Brief summary

The purpose of this study is whether Acetazolamide is effective in prevention of contrast nephropathy

Detailed description

Contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups.Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal salin respectively.We compare prevalence of contrast nephropathy in each group.

Interventions

DRUGsodium bicarbonate

150 meq/l Sodium bicarbonate 3cc/kg/hr before and 1cc/kg/hr after angiography

DRUGAcetazolamide

Acetazolamide 250 mg+ 1 cc/kg/hr normal salin before and after angiography

DRUGnormal salin

1 cc/kg/hr 6 hour before and after angiography

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* patient that underwent coronary angiography

Exclusion criteria

* serum Cr. more than 3 mg/dl * electrolyte and acid-base imbalance * pulmonary edema * allergy to Acetazolamide

Design outcomes

Primary

Measure	Time frame
Increased base line creatinine at least 25%	24 hr later

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026