FAP, Hereditary Diffuse Gastric Cancer, Juvenile Polyposis Syndrome, Lynch Syndrome, Peutz-Jeghers Syndrome
Conditions
Brief summary
After informed consent, participants will be asked to complete a medical/family history questionnaire and provide a blood sample. Participants will also be asked for their permission for study investigators to access medical records and/or recontact them for updates to their medical and family histories. Data and biospecimens will be stored for potential future research projects.
Interventions
OTHERResearch Registry
Information regarding medical and family history is stored in the registry to be used for potential future studies
Sponsors
University of Pittsburgh
Study design
Observational model
FAMILY_BASED
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
8 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Identified gene mutation * Personal history of colorectal cancer diagnosed ≤ 50 * Personal history of cancer with tumor studies suggestive of Lynch syndrome * Personal history of multiple primary tumors associated with a hereditary cancer syndrome (colorectal, uterus, stomach, ovary, small bowel, hepatobiliary tract, transitional cell carcinoma of the renal pelvis/ureter, brain) * Personal history of one of the above cancers and a family history of one or more of the above cancers * Personal or family history of diffuse gastric cancer * From a known genetic predisposition family * Personal history of \> 10 colon adenomas (cumulative over a lifetime) * Personal history of any number of hamartomatous polyps * Personal history of multiple large (\> 1cm) serrated polyps to right of sigmoid Exclusion critera: * Individuals under the age of 8 * Individuals who cannot travel to Pittsburgh for in-person enrollment * Individuals who cannot provide informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Establish a Hereditary Colorectal Tumor Registry to facilitate development and implementation of epidemiological, clinical and cancer control research. | 1-N/A (up to 8 years) |
Countries
United States
Outcome results
None listed