Efficacy of Vitamin C Injection on Fatigue in Workers After Work

Efficacy of High Dose Vitamin C Parenteral Supplement on Amelioration of Fatigue in Company Workers After Work: A Double-Blind, Randomized Controlled Trial

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00633581

Enrollment

150

Registered

2008-03-12

Start date

2008-03-31

Completion date

2008-05-31

Last updated

2009-04-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fatigue

Keywords

fatigue, ascorbic acid, oxidative stress

Brief summary

Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and the investigators seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work.

Detailed description

Previous studies dealing with vitamin C were focusing on terminal cancer patients or those with chronic fatigue syndrome. Since used drug dosage and the ways of administering vitamin C were not identical, the results were not consistent throughout those studies. This study is aimed to evaluate the efficacy of high dose vitamin C with parenteral supplement on relieving fatigue for apparently healthy volunteers.

Interventions

DIETARY_SUPPLEMENTAscorbic acid (Vitamin C)

Single intravenous injection of vitamin C 10g(20ml) with 100ml of normal saline over 30 minutes

DIETARY_SUPPLEMENTNormal saline

Single intravenous injection of 120ml of normal saline over 30 minutes

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 49 Years

Healthy volunteers

Yes

Inclusion criteria

* Company workers working at least 5 days a week from morning to evening * Volunteers who provided written informed consent

Exclusion criteria

* Acute illness * Chronic disease such as diabetes, hypertension, liver disease, or renal disease * Previous history of renal stone or gout * Pregnant or lactating women * Hypersensitivity to vitamins or intravenous injections * History of vitamin supplements orally or parenterally within 2 days

Design outcomes

Primary

Measure	Time frame
Degree of fatigue at the point of time with visual analogue scale from 0 to 10	Before intravenous vitamin C injection and right after completing injections, and one day later

Secondary

Measure	Time frame
Reactive oxygen species	Before intravenous vitamin C injections, right after completing injections, and one day later
Plasma vitamin C level	Before intravenous vitamin C injections and right after completing injections

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 27, 2026