Kidney Failure
Conditions
Keywords
hemodialysis
Brief summary
The purpose of this sudy is to determined the effect of dialysate volume and treatment time on phosphate and calcium removal in stage V chronickidney disease patients treated by hemodialysis using the System One (NxStage Medical, Lawrence, MA)
Detailed description
Ten patients will be recruited from those routinely treated in-center or at home using the Systerm One at the clinical centers. Each patient will be studiesd on 4 separate occastions. Treatments under the following conditions will each be performed on each study patient, at least one week apart: 1. Treatment for 8 hrs uding 40L of dialysate 2. Treatment for 8 hrs using 60L of dialysate 3. Treatment for 5 hrs using 40L of dialysate 4. Treatment for 5 hrs using 60L of dialysate Blood samples will be collected and assayed for the concentrations of urea, phosphate, calcium, bicarbonate, beta-2-microglobulin and albumin using standard assays.
Interventions
DEVICENxStage System One (NxStage Medical, Lawrence, MA)
Each patient will be studied on 4 separate occasions. The study sessions are longer than routine daily hemodialysis therapy using the System One.
Sponsors
Indiana University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Stage V chronic kidney patients with minimal or no residual renal functin
Exclusion criteria
* Medically unstable * Hematocrit less than 28% * Hepatitis B positive, hepatitis C positive or HIV positive * Pregnant women * Minors below 18 years of age * Active psychiatric disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the effect of dialysate volume and treatment time on phosphage and calcium removal | 4 treatments |
Outcome results
None listed