Periodontal Attachment Loss
Conditions
Brief summary
The purpose of this study is to test the hypothesis that dietary n-3 PUFA will have a beneficial effect on systemic and local markers of inflammation when combined with traditional, non-surgical periodontal therapy.
Interventions
DIETARY_SUPPLEMENTOmega-3 Fatty acid (with SRP or OHI)
1000mg capsules three times daily, duration 28 weeks.
DIETARY_SUPPLEMENTPlacebo
corn/soybean oil capsules 1g/three times daily
Sponsors
National Institutes of Health (NIH)
National Center for Research Resources (NCRR)
University of Kentucky
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. ≥ 18 years of age, male or female 2. At least 20 natural teeth present at the time of periodontal examination 3. Be diagnosed with severe, chronic periodontitis; 4. Be willing to participate in the study
Exclusion criteria
1. \<18 years of age 2. Less than 20 natural teeth present at time of periodontal examination 3. Unable or unwilling to provide informed consent or follow study protocol 4. Systemic conditions including diabetes mellitus and any cardiovascular condition that would require premedication prior to dental treatment 5. Use of systemic antibiotics within the last 3 months 6. Pregnancy as diagnosed by administered pregnancy test. 7. You are nursing a baby. 8. Are allergic to fish or fish products. 9. You are taking any other medications, such as dietary supplements, that could affect the outcome of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical attachment loss | baseline, 8, 16, 28 weeks |
Countries
United States
Outcome results
None listed