The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00632892

Enrollment

Registered

2008-03-11

Start date

2007-12-31

Completion date

Unknown

Last updated

2008-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Diseases

Keywords

oxidative stress markers in urine, urine norepinephrine, renal tubular enzyme markers

Brief summary

Clinically, iodinated contrast-medium (CM) is widely used in angiography and computerized tomography. CM-induced nephropathy (CMIN) is one major complication after application of CM. Therefore, how to prevent CMIN is always one of the hot topics concerned by nephrologists, cardiologists, and radiologists. The present study is aimed to determine the norepinephrine concentration, oxidative markers, and tubular damage markers in the urine samples of patients undergoing intravenous pyelography (IVP). The working hypothesis is high-osmolarity contrast media (HOCM) causes more oxidative stress and greater tubular damage than iso-osmolarity contrast media (IOCM).

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Adult patients (\> 18 years old) 2. Undergoing IVP with an appropriate medical indication 3. Signing informed consent

Exclusion criteria

1\. Without signing informed consent

Countries

Taiwan

Outcome results