Continuous Positive Airway Pressure and Oxygen Concentration on Measurement of Rapid Shallow Breathing Index

Effect of Continuous Positive Airway Pressure and Oxygen Concentration on Measurement of Rapid Shallow Breathing Index

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00632320

Enrollment

Registered

2008-03-10

Start date

2004-10-31

Completion date

2005-08-31

Last updated

2008-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Respiratory Failure

Keywords

Ventilator, mechanical, Ventilator weaning, Rapid shallow breathing index, Continuous positive airway pressure, Receiver operating characteristic curve, COPD

Brief summary

To compare the rapid shallow breathing index (RSBI) values, the incidence of adverse reactions, and the predictive accuracy measured under 5 different ventilator strategies in the same patient group.

Detailed description

98 ready for weaning patients were included and divided into success (n=71) and failure (n=27) groups based upon their weaning outcome. Before weaning, the RSBI values were determined under the patients disconnecting from the ventilator (RA-no ventilator) and still connecting to the ventilator with 4 different settings (fraction of inspired oxygen (FiO2) 21 or 40% combined with continuous positive airway pressure (CPAP) 0 or 5 cm H2O). The patients were extubated after completing the weaning trials. Successful weaning was defined as patients free from the ventilator for over 48 hours.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* intubated medical patients with mechanically ventilated more than 48 hours * clinically ready for weaning * Glasgow coma scales were at least 8 * their ventilator settings were: assist-controlled, pressure support (PS)or synchronized intermittent mandatory ventilation plus PS mode, FiO2 40% or less, positive end-expiratory pressure 5 cm H2O or less, and sensitivity setting on 1 L/min. Their arterial blood gases results were acceptable

Exclusion criteria

* having ongoing lung or neuromuscular disease and signs of increased intracranial pressure

Design outcomes

Primary

Measure	Time frame
The patients connecting or disconnecting to the ventilators affected the RSBI values but not their predictive accuracies.	Before the patient processing weaning trials

Secondary

Measure	Time frame
Changes in FiO2 and CPAP settings have no effect on RSBI values but ventilator methods with FiO2 21% have higher incidence of adverse reactions.	Before the patient processing weaning trials

Countries

Taiwan

Outcome results