Hypertension
Conditions
Keywords
antihypertensive drugs, non-steroidal anti-inflammatory drugs, interaction, family practice, arterial blood pressure
Brief summary
NSAIDs may increase blood pressure and blunt the effects of many antihypertensives. Members of these drug classes differ in their propensity to such an interaction.
Detailed description
To compare prospectively the effects of piroxicam, ibuprofen and acetaminophen on blood pressure control in hypertensive patients with osteoarthritis.
Interventions
DRUGacetaminophen
acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os
DRUGibuprofen
acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os
DRUGpiroxicam
acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os
Sponsors
Dr Ivancica Pavlicevic Family Practice Office
University of Split
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
55 Years to 78 Years
Healthy volunteers
No
Inclusion criteria
* Treated hypertensives of either gender aged between 55 and 76 years * About 50% with concomitant osteoarthritis of the hip or knee
Exclusion criteria
* Normotensive persons or untreated hypertensives * Individuals outside the age limits * General
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial blood pressure | 3 months (3 individual blocks of 1 month each) |
Secondary
| Measure | Time frame |
|---|---|
| Body weight,serum electrolytes, urinary electrolytes (Na, K) | 3 months (3 periods of 1 month) |
Countries
Croatia
Outcome results
None listed