Lateral Epicondylalgia (Tennis Elbow)
Conditions
Keywords
tendinopathy, tennis elbow, lateral epicondylitis, lateral epicondylalgia, MMP-inhibitor
Brief summary
Matrix metalloproteinases are involved in the pathogenesis of tendinopathy. Doxycycline, a widely available pharmaceutical agent mostly used for its antibiotic properties, also functions as an inhibitor of MMPs. This study aims to investigate the effect of doxycycline treatment on lateral epicondylalgia (tennis elbow). During three weeks, patients receive doxycycline tablets 100 mg twice daily, or placebo. Main outcome variable is pain (VAS) at three weeks. Serum and/or plasma levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases are measured.
Interventions
DRUGPlacebo
DRUGDoxycycline
Sponsors
University Hospital, Linkoeping
Kaunas University of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-65 * Pain at the lateral side of the elbow ≥8 weeks * Local tenderness on palpation of the lateral epicondyle * Pain on resisted extension of the wrist
Exclusion criteria
* Rheumatic disorder * History of fibromyalgia or generalised pain * Elbow surgery (on the painful side) * Active infection * Glucocorticoid treatment during the duration of symtoms of epicondylalgia * NSAID use within 1 w before presentation and during the study * Pregnancy * Taking drug that might interact with doxycycline
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain (VAS) | — |
Countries
Lithuania
Contacts
Primary ContactAlfredas Smailys, MD, PhD
Outcome results
None listed