Genetic Polymorphisms of Interleukin-10 and TNF-α on Outcome of HCV-Related Chronic Liver Disease

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00630006

Enrollment

Unknown

Registered

2008-03-06

Start date

2007-01-31

Completion date

2008-12-31

Last updated

2008-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Liver Disease, Hepatitis C Virus Infection

Brief summary

The prognosis of chronic hepatitis C virus (HCV)infeciton varies from minimal progressive disease to cirrhosis or hepatocellular carcinoma. Host genetic factors contribute to disease severity. It is known that cytokine gene (including tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) polymorphism affect disease prognosis.This study aims to assess the effect of TNF-alpha and IL-10, and their interaction,on prognosis of HCV-related chronic liver disease

Interventions

GENETICTNF-alpha and IL-10

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Anti-HCV-positive patients

Exclusion criteria

* Anti-HCV-negative patients

Design outcomes

Primary

Measure	Time frame
cytokine gene polymorphism	years

Secondary

Measure	Time frame
cytokine gene polymorphism on severity of disease	years

Countries

Taiwan

Contacts

Primary ContactJen-Eing Jeng, M.D.

jejeng@cc.kmu.edu.tw886-7-3121101

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026