Prevention of the Age-Related Cognitive Impairment by Exercise and Mental Activity - Berlin Bleibt Fit

Randomized, Controlled Study About the Effects of an Exercise Program and Mental Activity on the Age-Associated Impairment of Cognitive Function

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00629174

Acronym

BBF

Enrollment

252

Registered

2008-03-05

Start date

2006-06-30

Completion date

Unknown

Last updated

2008-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognition, Mood

Keywords

Cognitive function, Elderly, Exercise, Mental activity

Brief summary

The trial will evaluate the effects of frequent exercise and increased mental activity on the age-related impairment of cognitive function in elderly women. Furthermore, we will assess the effects of exercise and mental activity on the mood, physical performance and mental status of participants. We will also search for genetic factors which may be responsible of the observed outcomes.

Detailed description

Two-hundred and fifty-two women older than 70 years will be randomize to one of three groups. The first (exercise) will participate at an exercise program three times weekly for 90 minutes. The training will consist of an endurance and resistance training and will be carried out in a group. Participants in the second group (mental training) will take computer lessons, three times weekly for 90 minutes. Both interventions will be carried out for 26 weeks. Participants in the third group (control) will not participate at an structured intervention.

Interventions

BEHAVIORALExercise

Endurance and resistence training, 90 minutes, 3 times weekly

BEHAVIORALMental activity

Participation at computer lessons, 3 times weekly, 90 minutes each

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

70 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* All healthy women older than 70 years with sufficient knowledge of German can participate.

Exclusion criteria

* Chronic mental disorders * Chronic neurological, cardiological, pulmonary or renal diseases. * Severe osteoarthritis * Disorders which can be aggravated by exercise (arterial hypertension, coronary heart disease, COLD). * Cancer in current therapy * Treatment with glucocorticoids or cytostatic drugs. * Patients who received an organ transplantation * Exercise-induced osteoarticular pain

Design outcomes

Primary

Measure	Time frame
Improvement of cognitive and physical performance	6 months

Countries

Germany

Contacts

Primary ContactFernando Dimeo, MD

fernando.dimeo@charite.de+49308445

Backup ContactSarah Dauven

sarah.dauven@charite.de

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026