Heart Failure, Diastolic
Conditions
Keywords
Cardiac Energetics, Dynamic Diastolic filling Assessment, Heart Failure with Preserved Ejection Fraction, Arterial and Ventricular Stiffening
Brief summary
Up to half of all patients with heart failure are found to have normal pumping function of the heart muscle, but show abnormalities in the way the heart muscle relaxes and fills with blood. These patients often have high blood pressure, and tend to have stiff arteries and stiff heart muscle. We wish to test the hypothesis that these patients have abnormal energy stores in their heart muscle.
Interventions
None listed
Sponsors
Heart of England NHS Trust
British Heart Foundation
University Hospital Birmingham
Study design
Observational model
COHORT
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Clinical features consistent with heart failure * LVEF ≥ 50%, with no evidence of significant valvular disease, no hypertrophic cardiomyopathy, and no evidence of pericardial constriction * A peak VO2 \< 80% predicted, with a pattern of gas exchange on metabolic exercise testing indicating a cardiac cause for limitation
Exclusion criteria
* Objective evidence of lung disease on formal lung function testing * Reversible myocardial ischaemia on contrast-enhanced myocardial stress * Echocardiography, and evidence of exercise-induced mitral regurgitation * Obesity (BMI \>35) or a locomotor cause for exercise limitation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete echocardiographic assessment to assess resting diastolic function | 1 DAY |
| Assessment of resting large artery function | 1 DAY |
| Multiple Gated Acquisition Scan | 1 DAY |
| Cardiac Magnetic Resonance Spectroscopy | 1 DAY |
| Metabolic Exercise Testing (VO2max) | 1 DAY |
Countries
United Kingdom
Contacts
Primary ContactThanh T Phan, MRCP
Outcome results
None listed