Oral Glucocorticosteroid in the Treatment of Severe Asthma Exacerbation in Hospitalized Patients

Phase 4, Randomized Study of Oral Glucocorticosteroid Administration in the Treatment of Acute Severe Asthma Exacerbation in Hospitalized Patients

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00627731

Enrollment

Registered

2008-03-03

Start date

2007-06-30

Completion date

2009-10-31

Last updated

2011-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma

Keywords

Asthma Patients

Brief summary

A comparison of oral prednisolone administration with intravenous methylprednisolone infusion in the treatment of acute asthma exacerbation in hospitalized patients. Oral glucocorticosteroids administration may be effective as intravenous high-dose methylprednisolone infusion.

Interventions

DRUGmethylprednisolone sodium succinate (mPSL)

mPSL IV 240mg per day for 5 days and oral PSL 40mg per day for 5 days

DRUGprednisolone (PSL)

PSL 40 mg per day for 10 days

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

16 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Asthma patients, who need hospitalized treatment, who do not respond with initial treatment including bronchodilator and IV methylprednisolone therapy

Exclusion criteria

* Need for incubation * With severe complications * Received systemic glucocorticosteroid therapy in the previous 4 weeks

Design outcomes

Primary

Measure	Time frame
Efficacy of oral prednisolone for the treatment of acute asthma	three-year

Secondary

Measure	Time frame
The safety of oral prednisolone for the treatment of acute asthma	three-year

Countries

Japan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026