Efficacy of PEG-400 and Systane Artificial Tears (Alcon) on Quality of Vision

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00627302

Enrollment

Registered

2008-03-03

Start date

2008-02-29

Completion date

2008-11-30

Last updated

2008-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myopia

Keywords

Quality of Vision

Brief summary

To evaluate the effect of PEG-400 and Systane on quality of vision after LASIK.

Interventions

DRUGPEG-400

Day of Surgery: Starting 2 hours after surgery Instill one drop in randomized eye every two hours. Day 1-Week 1: Instill one drop in randomized eye four times daily

DRUGSystane

Day of Surgery: Starting 2 hours after surgery Instill one drop in randomized eye every two hours. Day 1-Week 1: Instill one drop in randomized eye four times daily

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

21 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Males or females \> 21 years old * Scheduled to undergo bilateral LASIK * Likely to complete all study visits and able to provide informed consent

Exclusion criteria

* Prior or current use of topical cyclosporine within the last 1 year * Known contraindications to any study medication or ingredients * Ocular disorders * Active ocular diseases or uncontrolled systemic disease * Active ocular allergies * Complications at the time of surgery

Design outcomes

Primary

Measure	Time frame
Quality of vision	5 months

Secondary

Measure	Time frame
Efficacy	5 months

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026