General Anesthesia
Conditions
Brief summary
The association of general anesthesia and of thoracic epidural anesthesia is used in thoracic surgery with a demonstrated benefit on the risk of postoperative respiratory complications. The objective of the study is to analyze the influence of thoracic epidural administration of chirocaine (5 mg/ml) on the administration of anesthetic agents (propofol and remifentanil), these drugs being administrated using a closed-loop system with the Bispectral Index as the controller. Two groups of patients are compared: * one group will receive general anesthesia and thoracic epidural administration of saline. Chirocaine will be administered before patient's awakening, * one group will receive general anesthesia and thoracic epidural administration of chirocaine (5 mg/ml). In both groups, the closed-loop system ensures that le depth of anesthesia is similar in both groups.
Interventions
DRUGremifentanil
dosage
Sponsors
Hopital Foch
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients undergoing a thoracotomy under general anesthesia and epidural anesthesia
Exclusion criteria
* age lower than 18 years, * pregnant woman, * psychotropic treatment, * central neurological disorder or lesion cerebral, * allergy to propofol or to a muscle relaxant, * refusal or contra-indication of epidural anesthesia, * severe emphysema, * coronary disease, * treatment with a beta-blocker or a vasoactive drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| amount of remifentanil delivered by the closed-loop system | end of anesthesia |
Secondary
| Measure | Time frame |
|---|---|
| amount of propofol delivered by the closed-loop system | end of anesthesia |
Countries
France
Outcome results
None listed