Prevention of Coronary Heart Disease in Morbidly Obese Patients

Conditions

Hypertension, Morbid Obesity, Obstructive Sleep Apnea, Osteoarthrosis, Type 2 DM

Keywords

Arterial stiffness, PulseWave velocity, Body composition, Bioimpedance, Morbid Obesity, APO A, APO B, Framingham risk score, Prevention of Coronary Heart Disease, Lifestyle Intervention, Bariatric Surgery, Low Energy Diet

Brief summary

The changes in risks of developing coronary heart disease in patients with morbid obesity after different weight loss interventions have not been extensively studied. The primary objective of this study is to investigate whether an intensive lifestyle intervention program in a tertiary care clinic (Spesialsykehuset for Rehabilitering) is comparable with a 7-week low-energy-diet followed by bariatric surgery in decreasing the risk of cardiovascular disease in these patients.

Detailed description

Patients matching the eligibility criteria were divided into two groups (not randomized). One group underwent a 7 weeks Low-Energy-Diet before bariatric surgery, the other group participated in an intensive lifestyle intervention program for 3 months. Data on arterial stiffness, body weight, body composition, blood pressure, blood samples, vital parameters are registered in the both groups at baseline, 7 weeks and after 1 year.

Young J, Seeberg KA, Aakre KM, Borgeraas H, Nordstrand N, Wisløff T, Hjelmesæth J, Omland T, Hertel JK.

2023-11-223 citations

10.1016/j.clinbiochem.2023.110688

Differential effects of bariatric surgery and lifestyle interventions on plasma levels of Lp(a) and fatty acids

Kirsten A. Berk, Heidi Borgeraas, Ingunn Narverud, Monique T. Mulder, Linn K. L. Øyri et al. (14 authors)

Lipids in Health and Disease2022-12-2812 citations

10.1186/s12944-022-01756-1

The relationship between various measures of obesity and arterial stiffness in morbidly obese patients.

Nordstrand N, Gjevestad E, Dinh KN, Hofsø D, Røislien J, Saltvedt E, Os I, Hjelmesæth J.

2011-02-0154 citations

10.1186/1471-2261-11-7

Interventions

PROCEDUREBariatric Surgery

Bariatric Surgery Treatment: Duodenal Switch, Gastric Sleeve or Gastric bypass.

BEHAVIORALConservative Treatment:

Intensive Lifestyle Intervention Program

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

No

Inclusion criteria

* Morbidly Obese patients with BMI \> 40, or BMI \> 35 with comorbidity such as Hypertension, Obstructive Sleep Apnea, Weight Related Osteoarthrosis, Type 2 DM.

Exclusion criteria

* Participation in other weight loss program the last 12 months. Serious psychiatric conditions

Design outcomes

Primary

Measure	Time frame	Description
Arterial stiffness	7 weeks and 1 year	Pulse wave velocity and augmentation index
Cardiovascular risk factors	7 weeks and 1 year	Several biomarkers will be examined

Countries

Norway

Outcome results

None listed