Primary Open Angle Glaucoma
Conditions
Keywords
primary open angle glaucoma, Nuclear Genetics, Mitochondrial DNA, POAG
Brief summary
Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases. So far, research has only been able to find the genes responsible for glaucoma in a small percentage of people who have glaucoma. The purpose of this project is to study the genes in patients with and without glaucoma to find additional genes that may be responsible for causing glaucoma.
Detailed description
Four tubes of blood will be taken from 100 people. Of those, half will have primary open angle glaucoma (POAG) and the other half will be controls (normals), half will be caucasians and the other half will be african americans, half male and half female. All groups will have a routine ophthalmic eye exam, color vision, snellen vision, and visual field done.
Interventions
None listed
Sponsors
Jefferson Medical College of Thomas Jefferson University
Thomas Jefferson University
Wills Eye
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 40 yrs * Caucasian or African American * Male or female with POAG, PACG, PXFG, * Normal
Exclusion criteria
* Other ophthamic co-morbidities * Other ethnic groups * Unable to understand and give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The investigators will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma. | one blood draw |
Countries
United States
Outcome results
None listed