Aortic Dimensions in Turner Syndrome

Aortic Dimensions, 24hour Ambulatory Blood Pressure and Sympathovagal Tone in Turner Syndrome. In Relation to Aortic Dilatation and Dissection.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00624949

Enrollment

102

Registered

2008-02-28

Start date

2003-08-31

Completion date

2012-06-30

Last updated

2008-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Turner Syndrome

Keywords

Turner syndrome, aortic dimensions, blood pressure, aortic dilatation, aortic rupture

Brief summary

An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure. It has been found that besides an significantly increased risk of congenital cardiac malformations, TS have an increased risk of developing cardiac disease including the life threatening condition of aortic dilatation and rupture. The aim of the study is to describe the cardiac conditions of TS, evaluate different methods of examination and identify possible risc factors.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Turner syndrome * Age 18-70 years

Exclusion criteria

* Extreme adipositas * Contraindications to a MRI scan * Malignant disease

Design outcomes

Primary

Measure	Time frame
Aortic diameter at 3 well-defined levels measured by MRI and ECHO	2-yearly for 6 years

Secondary

Measure	Time frame
24hour ambulatory blood pressure	24h 2-yearly for 6 years

Outcome results