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Velocity Vector Imaging in Patients With Moderate-to-Severe Aortic Regurgitation

Velocity Vector Imaging in Patients With Moderate-to-Severe Aortic Regurgitation

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00624884
Enrollment
50
Registered
2008-02-28
Start date
2008-03-31
Completion date
2008-05-31
Last updated
2008-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Regurgitation

Keywords

Aortic regurgitation,velocity vector imaging

Brief summary

Velocity Vector Imaging may provide reliable and detailed information on left ventricular segmental function in asymptomatic patients with moderate-to severe AR. This may help to identify subclinical myocardial dysfunction in order to operate early enough to prevent postoperative heart failure and restrict unnecessary early operation which could be associated with operative risks and mortality related to prosthetic valves.

Detailed description

Chronic aortic regurgitation (AR) is a progressive process which causes both left ventricular volume and pressure overload. While the volume overload is associated with the degree of the aortic regurgitant volume, the pressure overload occurs as a result of systemic hypertension developed due to increased stroke volume. In early stages, excentric hypertrophy occurs aiming to compensate the volume overload in the left ventricle. Therefore , ejection fraction remains in normal range despite the increasing volume overload. Left ventricular dilatation and impairment in ejection fraction only occur in the end stages of the disease. Asymptomatic patients with chronic aortic regurgitation (AR) have a good prognosis in the presence of preserved systolic function. Therefore it is a challenge to identify patients with subclinical left ventricular (LV) dysfunction. Velocity vector imaging (VVI) is a new echocardiographic method based on two dimensional gray scale imaging, which is angle independent and can provide more accurate data about cardiac function.

Interventions

None listed

Sponsors

Florence Nightingale Hospital, Istanbul
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes

Inclusion criteria

* Moderate-to-severe aortic regurgitation identified by Standard echocardiography. * Chronic isolated aortic regurgitation * Being asymptomatic ( Class 1 according to NYHA) * Sinusal rhythm

Exclusion criteria

* Ejection fraction \< 50% * Mitral valve disease accompanied to aortic regurgitation (patients with over mild degree of mitral regurgitation and stenosis * Aortic stenosis * Previous myocardial infarction, or the patients with \>50% coronary occlusion in any of the coronary arteries. * Cardiomyopathies * AV conduction disorders * Chronic renal or hepatic insufficiency * Malignities

Design outcomes

Primary

MeasureTime frame
Velocity Vector Imaging derived segmental systolic peak Strain and Strain ratesApril 2008

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026