Infant
Conditions
Keywords
Body composition, Glucose tolerance, Intima-media thickness, Visual acuity, Neurological development
Brief summary
Formula-fed infants differ from breast-fed infants in the growth pattern, risk for obesity and cardiovascular diseases, neurological development and morbidity in infections. The investigators' hypothesis is that a modified formula with reduced energy and protein content and enrichment with Milk Fat Globule Membrane (MFGM) containing bioactive proteins and phospholipids will reduce the difference between formula-fed and breast-fed infants.
Interventions
DIETARY_SUPPLEMENTModified formula (MFGM-enriched formula with reduced energy and protein content)
MFGM-enriched formula with reduced energy and protein content
Sponsors
Umeå University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
No minimum to 2 Months
Healthy volunteers
Yes
Inclusion criteria
* Term infants with birth weight 2500-4500 gr * Fed with breastmilk only or formula only before 2 months of age
Exclusion criteria
* Chronic illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Body composition | 4 months | Pletysmography (% body fat) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neurological development | 1 year | Bayley Scales of Infant and Toddler Development, 3rd Ed (higher score - better outcome) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Neurological development | 6.5 years | Wechsler Intelligence Scale for Children, 4th Ed (higher score - better outcome) |
Countries
Sweden
Outcome results
None listed