Single Transpulmonary Thermodilution and Continuous Monitoring of Central Venous Oxygen Saturation During Off-pump Coronary Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00624494

Acronym

OPCAB

Enrollment

Registered

2008-02-27

Start date

2005-05-31

Completion date

2008-09-30

Last updated

2024-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease, Goal Directed Therapy, Hemodynamic Monitoring

Keywords

venous oxygen saturation, transpulmonary thermodilution

Brief summary

The aim of the present study was to evaluate the usefulness of an algorithm based on hemodynamic parameters obtained by single transpulmonary thermodilution (STD) combined with continuous monitoring of central venous oxygen saturation (ScvO2) for perioperative management of patients undergoing OPCAB.

Detailed description

At the present time, there is an increasing tendency to perform off-pump coronary artery bypass grafting (OPCAB). However, OPCAB poses a variety of challenges from the point of view of the anesthesiologist and the intensivist. The aim of the present study was to evaluate the usefulness of an algorithm based on hemodynamic parameters obtained by single transpulmonary thermodilution (STD) combined with continuous monitoring of central venous oxygen saturation (ScvO2) for perioperative management of patients undergoing OPCAB.

Interventions

DEVICEConventional monitoring

In the CM group, therapy was guided by central venous pressure, mean arterial pressure (MAP) and heart rate (HR)

DEVICEAdvanced monitoring

In the AM group by the intrathoracic blood volume index, MAP, HR, central venous oxygen saturation (ScvO2) and cardiac index (CI). The measurements were performed before and during surgery, and at 2, 4 and 6 hrs post-operatively.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Patients with coronary artery disease, ranked ASA II-III and scheduled for elective OPCAB

Exclusion criteria

* Age \< 18 years * Severe valve dysfunction or peripheral vascular disease * Simultaneous interventions (carotid endarterectomy, aneurysm repair, etc.) * Transfer to CPB during surgery

Design outcomes

Primary

Measure	Time frame	Description
length of hospital stay	one month	Length of the hospital stays, Days

Countries

Russia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026