Use of Atropine in Tredmill Stress Testing

Safety and Feasibility of Atropine Added During Treadmill Stress Testing in Patients With Chronotropic Incompetence or Poor Exercise Capacity.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00623207

Enrollment

103

Registered

2008-02-25

Start date

2007-12-31

Completion date

2009-10-31

Last updated

2015-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chest Pain

Keywords

Chest Pain Low work Capacity Rate Incompetence

Brief summary

The aim of this study is to evaluate the Safety and feasibility of atropine added during treadmill stress testing in patients with chronotropic incompetence or poor exercise capacity. Our hypothesis is that we can increase heart rate by using atropin in these patients, so we will achieve more conclusive results.

Interventions

DRUGAtropine

I.V Atropine 0.5mg up to 2 mg

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with chest pain without evidence of ischemia eligible for exercise test. * Age\> 18 years old

Exclusion criteria

Absolute: * Patients with LBBB * Unstable Angina * Recent Myocardial Infarction * Un controlled Arrythmia * Congestive heart faliure * Severe symptomatic valvular heart disease * Acute Pulmonary Embolism * Acute perimyocarditis * Acute aortic dissection Relative: * Lt main stenosis * Severe hypertention (Systolic\> 200 mmHg; Diastolic \> 100 mmHg) * Cardiomyopathy * Obstructiove abnormalities * Psychiatric disorders * High degree AV Block

Design outcomes

Primary

Measure	Time frame
1- To characterize patients who can't achieve target heart rate at treadmill exercise test.2- To evaluate atropine added during treadmill stress testing in order to increase heart rate and achieave conclusive test.	1 yaer

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026