Multiple Trauma
Conditions
Keywords
multiple trauma
Brief summary
The purpose of this study is to determine whether Erythropoietin decrease stress responses and inflammation in trauma patient.
Detailed description
Transfusion of blood products has many disadvantages. Erythropoietin is used to increase red blood cells production and decrease such disadvantages.In some studies anti inflammatory effects is shown for Erythropoietin. One of the most problems in the intensive care unit is stress response. we are going to evaluate effects of erythropoietin on oxidative stress and inflammation in trauma patient in intensive care unit.
Interventions
DRUGerythropoietin
300mg/kg erythropoietin 3 times on the first week of admission
DRUGplacebo
placebo
Sponsors
Tehran University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* All multiple trauma patients\>16 years with informed consent
Exclusion criteria
* Hypertension * Allergy * Erythroid leukemia * Pregnancy and breast feeding * Pre operative patient * Severe cardiovascular and cerebrovascular diseases * Thromboembolic disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| apachi 2 saps 30 days mortality | untill discharge |
Secondary
| Measure | Time frame |
|---|---|
| 30 days mortality | 30 days |
Countries
Iran
Contacts
Primary Contactmojtaba mojtahedzade
Backup Contactmostafa mohammady
Outcome results
None listed