Cardiopulmonary Bypass, Coronary Artery Bypass Graft, Coronary Artery Disease
Conditions
Keywords
Cardiopulmonary bypass, coronary artery bypass graft, coronary artery disease, propofol, pharmacokinetics, pharmacodynamics
Brief summary
Cardiopulmonary bypass (CPB) is known to alter pharmacokinetics (PK) and brain sensitivity to several drugs, including propofol. Few studies, however, have tested if propofol pharmacokinetical alterations observed after CPB could contribute to the increased hypnotic effect of propofol after CPB. This study was designed to test the hypothesis that changes in the PK of propofol contribute to an increase in its hypnotic effects after CPB as evidenced by changes in bispectral index (BIS) values. Twenty undergoing coronary artery bypass graft patients will be allocated in two groups: 1) CPB groups and 2) off-pump coronary artery bypass graft. Bispectral Index values and blood samples for plasma propofol concentration measurements will be collected along the surgery and up to 12 hours in the post-operative period. Plasma propofol concentrations, Bispectral index values and propofol PK will be compared between the groups.
Interventions
None listed
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
University of Sao Paulo
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Isolated coronary artery bypass indication * Left ventricular ejection fraction greater than 50 % * Absence of preoperative pulmonary dysfunction
Exclusion criteria
* Intra and postoperative circulatory shock * Postoperative pulmonary dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Propofol pharmacodynamics and pharmacokinetics | — |
Countries
Brazil
Outcome results
None listed