Serial BNP Testing for Heart Failure Management

Utilizing, Studying, Evaluating BNP for Monitoring in Patients With Heart Failure (USE-BNP)

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00622531

Acronym

USE-BNP

Enrollment

108

Registered

2008-02-25

Start date

2007-01-31

Completion date

2009-07-31

Last updated

2015-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Keywords

heart failure, BNP, natriuretic peptide

Brief summary

The scope of the USE-BNP Trial is to investigate whether knowledge of BNP measurements, in conjunction with clinical assessment, in the outpatient setting can guide the management of therapy in patients with heart failure.

Interventions

DEVICEBNP assay (Siemens ADVIA Centaur BNP)

Diagnostic test

OTHERhidden BNP value

no intervention

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Eligible subjects must be diagnosed with heart failure and have an abnormal BNP reading.

Design outcomes

Primary

Measure	Time frame
composite endpoint of all cause mortality, hospitalization due to worsening heart failure and administration of IV drug therapy for worsening heart failure.	12 months

Secondary

Measure	Time frame
NYHA classifications in the two treatment groups	12 months
Quality of life assessments of two treatment groups	12 months
change in therapy based on BNP usage	12 months
number of serious adverse events for the two groups	12 months

Countries

Canada, United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026