Acute Renal Failure
Conditions
Keywords
fenoldopam, acute renal failure, renal replacement therapy, mortality, cardiac surgery, cardiac anesthesia, intensive care unit
Brief summary
Patients undergoing cardiac surgery could develop postoperative acute renal failure requiring renal replacement therapy. Fenoldopam, already used for patients with hypertensive emergencies, could improve renal function in critically ill patients with or at risk for acute renal failure.
Interventions
DRUGfenoldopam
fenoldopam 0.1 ug/kg/min (from 0.025 to 0.3 ug/kg/min)for up to 4 days
DRUGplacebo
placebo
Sponsors
Università Vita-Salute San Raffaele
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* adult patients * who underwent cardiac surgery * have Risk of Acute Renal Failure (R of RIFLE score)
Exclusion criteria
* glaucoma * already on renal replacement therapy * study drug in the past 30 days * inclusion in other protocols
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients requiring Renal Replacement Therapy | participants will be followed for the duration of intensive care unit stay, an expected average of one week |
Secondary
| Measure | Time frame |
|---|---|
| Number of dead patients. | Participants will be followed for 1 year. |
Countries
Italy
Outcome results
None listed