Hypertension
Conditions
Keywords
candesartan, losartan, blood pressure, cardiovascular disease, health care consumption
Brief summary
This study is a Swedish historical cohort study in patients prescribed Atacand or Cozaar for hypertension by selected primary care centres. Data will be extracted anonymously from electronic medical records. In addition, data regarding morbidity and mortality will be collected by merging the cohort with the following national registries: the Hospital Discharge Register (Slutenvårdsregistret), the Cause of Death Register and the Heart Intensive Care Admission (RIKS-HIA)
Interventions
DRUGCandesartan Cilexetil
oral once daily dose
DRUGLosartan
once daily oral dose
Sponsors
AstraZeneca
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
17 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Recorded blood pressure prior to therapy of \> 140 and/or 90 mmHg * Diagnosed as hypertensive within 15 months * First prescription of Cozaar or Atacand between 1 January 1999 and 31 December 2007, inclusive
Exclusion criteria
* Previous prescription within 15 months any drug from the ATC groups C02, C03, C07 - C09 inclusive
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary efficacy objective is to investigate, on basis of 'first to event', the development of new cardiovascular diseases (CVD). | 1999 - 2007 |
Secondary
| Measure | Time frame |
|---|---|
| Cardiovascular disease states and procedures in the background and over the entire observation period will be identified by use of ICD-9 and ICD-10 coding for diseases of the cardiovascular system. Specifically are death, acute cardiovascular events, new | 1999 - 2007 |
| Health care consumption will be assessed as contacts with health care providers, in-hospital time periods for cardiovascular disease states with associated therapeutic procedures, and times spent within various levels of care (e.g. ICU and general ward). | 1999 - 2007 |
Countries
Sweden
Outcome results
None listed