Schizophrenia
Conditions
Keywords
schizophrenia, genetics, family, multiplex, haplotypes
Brief summary
Genetic etiology in schizophrenia is widely accepted. However, many chromosomal sites were shown to characterize the families of patients with schizophrenia. This is probably due to the high genetic heterogenity of this illness. Thus, it is important to investigate the genetic factor in relatively genetically homogenous populations. Many studies have indicate that Ashkenazy Jews show relative gentic homogenity. Indeed, the genes responsible for most Mendelian disorders of Jewish peoples have been identified. The study will apply genome-wide mutation screening methods to identify candidate allells in subjects of Ashkenazi Jewish ancestry with multiplex schizophrenia.
Interventions
None listed
Sponsors
Sheba Medical Center
Study design
Observational model
FAMILY_BASED
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 78 Years
Healthy volunteers
No
Inclusion criteria
1. Age 18+; 2. Meet DSM-IV criteria for Schizophrenia; 3. At least one first-degree relative who Meet DSM-IV criteria for Schizophrenia; 4. Can sign the informed consent form.
Exclusion criteria
1. Patients suffering from terminal or incurabale disease; 2. Minors, incompetents
Countries
Israel
Contacts
Primary ContactRaz Gross, MD, MPH
Outcome results
None listed