Coronary Vasospasm
Conditions
Keywords
Coronary Vasospasm, Endothelium, Vascular, Vasodilation, Hyperemia
Brief summary
Non-obstructive coronary artery disease (NOCAD) frequently accounts for myocardial ischemia in women. Endothelial dysfunction is a pathogenic factor in coronary spastic angina (CSA). CSA is an important cause of NOCAD diagnosed invasively by coronary angiography (CAG). Digital reactive hyperemia peripheral arterial tonometry (RH-PAT) provides noninvasive evaluation of endothelial dysfunction. The investigators hypothesized that the fingertip RH-PAT could predict the presence of CSA in women.
Detailed description
Outline of methods: RH-PAT was measured in women with chest pain prior to CAG. Coronary spasm was diagnosed by intra-coronary acetylcholine (ACh) provocation test. Using Flow-Wire, we assessed coronary endothelial function by coronary blood flow increase in response to ACh (ACh-CBF) and coronary flow reserve was assessed by adenosine (Ad-CFR).
Interventions
None listed
Sponsors
Kumamoto University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
40 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Stable post-menopausal women complaining angina-like chest pain
Exclusion criteria
* Severe valvular disease * Hypertrophic cardiomyopathy * Severe peripheral artery disease * Uncontrolled hypertension * Severe collagen diseases * Acute coronary syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ischemic heart disease diagnosed by cardiac catheterization | From Aug 2006 to May 2009 |
Countries
Japan
Outcome results
None listed