Steroid Before Thyroidectomy

Does a Single Dose of Steroid Before Thyroidectomy Improve Postoperative Nausea, Pain and Vocal Function?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00619086

Enrollment

Registered

2008-02-20

Start date

2005-11-30

Completion date

2007-06-30

Last updated

2008-06-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid Surgery for Benign Disease

Keywords

thyroidectomy, dexamethasone, steroid, nausea

Brief summary

We evaluated the effects of giving a single dose of steroid before thyroid surgery in a single institutional, double-blinded, randomized controlled trial. Postoperative nausea, pain, and vocal function were significantly improved after steroid administration compared to controls.

Interventions

DRUGDexamethason Helvepharm ®

8 mg Dexamethason i.v. 45 minutes prior to surgery

DRUGPlacebo

100 ml sodium chloride i.v. 45 minutes prior to surgery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients undergoing thyroid surgery for benign disease

Exclusion criteria

* Depression * Chronic pain disorder * Insulin dependent diabetes mellitus * History of PONV * Pregnancy * Age \< 18 years * Received antiemetic therapy within 48 hours

Design outcomes

Primary

Measure	Time frame
Nausea	0-72 hours postoperative

Secondary

Measure	Time frame
Pain, vocal function	0-72 hours postoperative

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 4, 2026