Insulin Secretory Capacity in Insulin-independent Pancreas-Kidney Recipients Compared to Controls

Insulin Secretory Capacity in Insulin-independent Pancreas-Kidney Recipients Compared to Non-Diabetic Kidney Recipients, Insulin Independent Recipients of Beta-cell Grafts and Healthy Controls.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00618761

Enrollment

Registered

2008-02-20

Start date

2004-10-31

Completion date

2014-01-31

Last updated

2012-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Transplantation, Pancreas Transplantation

Keywords

glucose clamp, beta-cell

Brief summary

The purpose of this study is to compare functional beta-cell mass using the hyperglycaemic clamp test in insulin-independent pancreas-kidney recipients with that in non-diabetic kidney recipients and normal controls as well as with the partially previously reported data in beta-cell recipients.

Interventions

OTHERhyperglycemic clamp test

hyperglycemic clamp test

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* kidney pancreas recipients * kidney recipients * healthy volunteers * beta-cell recipients * immunosuppression with MMF-Tacrolimus * 1-4 years after transplantation

Exclusion criteria

* high doses of steroids * insulin dependent

Design outcomes

Primary

Measure	Time frame
insulin secretion during clamp test	time 0

Countries

Belgium

Contacts

Primary ContactChantal Mathieu, M.D., PhD.

chantal.mathieu@uz.kuleuven.ac.be0032/16/346994

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026